ZSWM2

Details:

UniProt Entry: Q8NEG5
Gene: ZSWIM2
Class: RING
Family: RING1
Protein length: 633
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2dip

Protein Sequence ▾

>Q8NEG5
MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE YMDFRVFLGN
PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG LGEREISDLL RGIHRVQTPQ
PGTNDENEHV EEDGYIKQKE IDSEDICSIC QELLLEKKLP VTFCRFGCGN SIHIKCMKIL
ANYQSTSNTS MLKCPLCRKE FAPLKLILEE FKNSSKLVAA AEKERLDKHL GIPCNNCKQF
PIEGKCYKCT ECIEYHLCQE CFDSCCHLSH TFTFREKRNQ KWRSLEKRAD EVVKYIDTKN
EIEEKMSHFQ EKQGQVYTPK HIVRSLPLQL ITKNSKLLAP GYQCLLCLKA FHLGQHTRLL
PCTHKFHRKC IDNWLFHKCN SCPIDGQVIY NPLTWKNSAV NGQAHQSVSN RDIIHLSKQK
EPDLFIPGTG LVLKQNRLGI LPSIPQCNFD ELNTPQSPKD AYENTTIDNL CSIKLDNSNS
KKLTYDYKIS QHFPRYLQDL PTVSFGKIPS QTLLPPIVHK NIVCPTAMES PCISGKFHTS
LSRMTKGCKC NNHNLKKTPA TKIREDNKRS TLLPEDFNLI VNWSTAKLSL SKRYSNCMGE
ITRKCSHLSR QPVSHSVNTK STELSLIIEG VQL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	632	Family	E3 ubiquitin-protein ligase Zswim2	IPR039903	PTHR21540
54	87	Domain	Zinc finger, SWIM-type	IPR007527	PS50966
54	86	Domain	Zinc finger, SWIM-type	IPR007527	PF04434
135	227	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
147	198	Domain	Zinc finger, RING-type	IPR001841	PS50089
147	197	Domain	Zinc finger, RING-type	IPR001841	SM00184
228	278	Homologous_superfamily	Zinc finger, ZZ-type superfamily	IPR043145	G3DSA:3.30.60.90
229	280	Domain	Zinc finger, ZZ-type	IPR000433	PS50135
231	271	Domain	Zinc finger, ZZ-type	IPR000433	PF00569
234	261	Domain	Zinc finger, ZZ-type	IPR000433	PS01357
303	390	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
343	384	Domain	Zinc finger, RING-type	IPR001841	PF13639
344	385	Domain	Zinc finger, RING-type	IPR001841	SM00184
344	385	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	Biological Process	IEA	GO_REF:0000107
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾


Q8NEG5	ZSWM2	Yes	Yes	No	No	—	No	E3-specific

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