DRC6

Details:

UniProt Entry: Q8NEE6
Gene: FBXL13
Class: Other E3 Components
Family: Receptor
Protein length: 735
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8NEE6
MTPELMIKAC SFYTGHLVKT HFCTWRDIAR TNENVVLAEK MNRAVTCYNF RLQKSVFHHW
HSYMEDQKEK LKNILLRIQQ IIYCHKLTII LTKWRNTARH KSKKKEDELI LKHELQLKKW
KNRLILKRAA AEESNFPERS SSEVFLVDET LKCDISLLPE RAILQIFFYL SLKDVIICGQ
VNHAWMLMTQ LNSLWNAIDF SSVKNVIPDK YIVSTLQRWR LNVLRLNFRG CLLRPKTFRS
VSHCRNLQEL NVSDCPTFTD ESMRHISEGC PGVLCLNLSN TTITNRTMRL LPRHFHNLQN
LSLAYCRRFT DKGLQYLNLG NGCHKLIYLD LSGCTQISVQ GFRYIANSCT GIMHLTINDM
PTLTDNCVKA LVEKCSRITS LVFTGAPHIS DCTFRALSAC KLRKIRFEGN KRVTDASFKF
IDKNYPNLSH IYMADCKGIT DSSLRSLSPL KQLTVLNLAN CVRIGDMGLK QFLDGPASMR
IRELNLSNCV RLSDASVMKL SERCPNLNYL SLRNCEHLTA QGIGYIVNIF SLVSIDLSGT
DISNEGLNVL SRHKKLKELS VSECYRITDD GIQAFCKSSL ILEHLDVSYC SQLSDMIIKA
LAIYCINLTS LSIAGCPKIT DSAMEMLSAK CHYLHILDIS GCVLLTDQIL EDLQIGCKQL
RILKMQYCTN ISKKAAQRMS SKVQQQEYNT NDPPRWFGYD REGNPVTELD NITSSKGALE
LTVKKSTYSS EDQAA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
148	398	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
152	198	Domain	F-box domain	IPR001810	PS50181
156	195	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
243	266	Repeat	Leucine-rich repeat	IPR001611	PF13516
244	269	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
295	320	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
323	348	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
349	374	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
375	400	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
399	529	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
425	450	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
451	475	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
478	503	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
504	529	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
530	692	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
553	578	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
554	576	Repeat	Leucine-rich repeat	IPR001611	PF13516
579	604	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
605	630	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
605	628	Repeat	Leucine-rich repeat	IPR001611	PF13516
630	651	Repeat	Leucine-rich repeat	IPR001611	PF13516
631	656	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
657	682	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0005929	cilium	Cellular Component	IEA	GO_REF:0000043
GO:0031514	motile cilium	Cellular Component	IEA	GO_REF:0000043
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033

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