GMCL2

Details:

UniProt Entry: Q8NEA9
Gene: GMCL2
Class: Other E3 Components
Family: Adaptor
Protein length: 526
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8NEA9
MGSSSSRVLG QPRRALAQQE QGARARGSAR RPDTGDDAAS YGFCYCPGSH KRKRSSGACR
YCDPDSHREE HEEEGDKQQP LLNTPARKKL RSTSKYIYQT LFLNGENSDI KICALGEEWR
LHKIYLCQSG YFSSMFSGSW KESSMNIIEL EIPDQNIDVD ALQVAFGSLY RDDVLIKPSR
VVAILAAACM LQLDGLIQQC GETMKETINV KTVCGYYTSV EIYGLDSVKK KCLEWLLNNL
MTHQNVKLFK ELGINVMKQL IGSSNLFVMQ VEMDVYTTLK KWMFLQLVPS WNGSLKQLLT
ETDVWFSKQR KDFEGMAFLE TEPGKPFVSV FRHLRLQYII SDLASARIIE QDGIVPSEWL
SSVYKQQWFA MLRAEQDREV GPQEINKEDL EGNSMRCGRK LAKDGEYYWC WTGFNFGFDL
LVIYTNGYII FKRNTLNQPR SGSVSLRPRR SIAFRLRLAS FDSSGKLVCS RTTGYQILIL
KKDQEQVVMN LDSRFLTFPL YICCNFLYIS PEKGIENNRH PENPEN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	523	Family	Germ cell-less protein-like	IPR043380	PTHR23231
84	237	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
97	206	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
99	206	Domain	BTB/POZ domain	IPR000210	PF00651
108	178	Domain	BTB/POZ domain	IPR000210	PS50097
108	208	Domain	BTB/POZ domain	IPR000210	SM00225

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007281	germ cell development	Biological Process	IEA	GO_REF:0000002
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0016363	nuclear matrix	Cellular Component	IEA	GO_REF:0000044
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0097602	cullin family protein binding	Molecular Function	IPI	PMID:14528312

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.