ZNRF1

Details:

UniProt Entry: Q8ND25
Gene: ZNRF1
Class: RING
Family: RING4
Protein length: 227
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 5ywr

Protein Sequence ▾

>Q8ND25
MGGKQSTAAR SRGPFPGVST DDSAVPPPGG APHFGHYRTG GGAMGLRSRS VSSVAGMGMD
PSTAGGVPFG LYTPASRGTG DSERAPGGGG SASDSTYAHG NGYQETGGGH HRDGMLYLGS
RASLADALPL HIAPRWFSSH SGFKCPICSK SVASDEMEMH FIMCLSKPRL SYNDDVLTKD
AGECVICLEE LLQGDTIARL PCLCIYHKSC IDSWFEVNRS CPEHPAD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
163	226	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
183	222	Domain	Zinc finger, RING-type	IPR001841	PF13639
184	224	Domain	Zinc finger, RING-type	IPR001841	PS50089
184	224	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0034138	toll-like receptor 3 signaling pathway	Biological Process	IDA	PMID:12471095
GO:0034139	regulation of toll-like receptor 3 signaling pathway	Biological Process	IDA	PMID:37158982
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:15618008
GO:0034143	regulation of toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:19289601
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	Biological Process	IDA	PMID:28593998
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0070936	protein K48-linked ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0160177	positive regulation of autophagosome-lysosome fusion	Biological Process	IGI	PMID:38360932
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IC	PMID:28593998
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000120
GO:0005768	endosome	Cellular Component	IDA	GO_REF:0000054
GO:0005829	cytosol	Cellular Component	IDA	PMID:22797923
GO:0030672	synaptic vesicle membrane	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


Q8ND25	ZNRF1	Yes	No	No	No	—	No	E3-specific
Q03135	CAV1	Yes	Yes	No	No	—	No	E3-specific
P15104	GLNA	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8ND25	ZNRF1	Yes	No	No	No	—	No	E3-specific
Q03135	CAV1	Yes	Yes	No	No	—	No	E3-specific
P15104	GLNA	Yes	Yes	No	No	—	No	E3-specific