RN169

Details:

UniProt Entry: Q8NCN4
Gene: RNF169
Class: RING
Family: RING9
Protein length: 708
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 5gg4, 5vey

Protein Sequence ▾

>Q8NCN4
MAAAGPSTRA SSAAAAAALS RRGRRGRCDE TAAAKTGAPG PASGPSLLVL SPPLLQPPLP
PRPEESGCAG CLEPPGEAAA LPCGHSLCRG CAQRAADAAG PGCPRCRARG PGWARRRARD
DGQADSEVLG ECARRSQPER CRPRRDGGAA AAGPRPEQEP RAAPAEPDFI FRAPIKLSKP
GELREEYESL RKLREEKLQE EKPSEDQIHK LLPEDTETGK RKMDEQKKRD EPLVLKTNLE
RCPARLSDSE NEEPSRGQMT QTHRSAFVSK NNSYSLAFLA GKLNSKVERS QSCSDTAQER
AKSRVRAVPG NKAKVTTMTP ASNPIIGVLL STQNNRCVSA PDLTIEKRLP FSSLSSLASL
HKPERSVSPE SNDSISEELN HFKPIVCSPC TPPKRLPDGR VLSPLIIKST PRNLNRSLQK
QTSYEASPRI LKKWEQIFQE RQIKKTLSKA TLTSLAPEMG EELLGSEGIH SSKEKPLVAV
NTRLSGGQVL SEYTGPTSAD LDHFPSVSQT KAEQDSDNKS STEIPLETCC SSELKGGGSG
TSLEREQFEG LGSTPDAKLD KTCISRAMKI TTVNSVLPQN SVLGGVLKTK QQLKTLNHFD
LTNGVLVESL SEEPLPSLRR GRKRHCKTKH LEQNGSLKKL RQTSGEVGLA PTDPVLREME
QKLQQEEEDR QLALQLQRMF DNERRTVSRR KGSVDQYLLR SSNMAGAK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
60	154	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
68	106	Domain	Zinc finger, RING-type	IPR001841	SM00184
68	107	Domain	Zinc finger, RING-type	IPR001841	PS50089
83	92	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IDA	PMID:23333306
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IDA	PMID:22492721
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006302	double-strand break repair	Biological Process	IBA	GO_REF:0000033
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000108
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:2000780	negative regulation of double-strand break repair	Biological Process	IMP	PMID:22492721
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0035861	site of double-strand break	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031491	nucleosome binding	Molecular Function	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0061649	ubiquitin-modified histone reader activity	Molecular Function	IDA	PMID:22492721
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Molecular Function	IDA	PMID:22492721

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.