ZBT34

Details:

UniProt Entry: Q8NCN2
Gene: ZBTB34
Class: RING
Family: RING6
Protein length: 500
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q8NCN2
MDSSSFIQFD VPEYSSTVLS QLNELRLQGK LCDIIVHIQG QPFRAHKAVL AASSPYFRDH
SALSTMSGLS ISVIKNPNVF EQLLSFCYTG RMSLQLKDVV SFLTAASFLQ MQCVIDKCTQ
ILESIHSKIS VGDVDSVTVG AEENPESRNG VKDSSFFANP VEISPPYCSQ GRQPTASSDL
RMETTPSKAL RSRLQEEGHS DRGSSGSVSE YEIQIEGDHE QGDLLVRESQ ITEVKVKMEK
SDRPSCSDSS SLGDDGYHTE MVDGEQVVAV NVGSYGSVLQ HAYSYSQAAS QPTNVSEAFG
SLSNSSPSRS MLSCFRGGRA RQKRALSVHL HSDLQGLVQG SDSEAMMNNP GYESSPRERS
ARGHWYPYNE RLICIYCGKS FNQKGSLDRH MRLHMGITPF VCKFCGKKYT RKDQLEYHIR
GHTDDKPFRC EICGKCFPFQ GTLNQHLRKN HPGVAEVRSR IESPERTDVY VEQKLENDAS
ASEMGLDSRM EIHTVSDAPD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
6	138	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
8	123	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
22	124	Domain	BTB/POZ domain	IPR000210	PF00651
32	126	Domain	BTB/POZ domain	IPR000210	SM00225
32	96	Domain	BTB/POZ domain	IPR000210	PS50097
372	394	Domain	Zinc finger C2H2-type	IPR013087	SM00355
372	399	Domain	Zinc finger C2H2-type	IPR013087	PS50157
373	403	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
374	394	Domain	Zinc finger C2H2-type	IPR013087	PS00028
374	394	Domain	Zinc finger C2H2-type	IPR013087	PF00096
394	446	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
400	422	Domain	Zinc finger C2H2-type	IPR013087	PF00096
400	422	Domain	Zinc finger C2H2-type	IPR013087	SM00355
400	427	Domain	Zinc finger C2H2-type	IPR013087	PS50157
402	422	Domain	Zinc finger C2H2-type	IPR013087	PS00028
428	456	Domain	Zinc finger C2H2-type	IPR013087	PS50157
428	451	Domain	Zinc finger C2H2-type	IPR013087	SM00355
428	451	Domain	Zinc finger C2H2-type	IPR013087	PF00096
430	451	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0000785	chromatin	Cellular Component	ISA	GO_REF:0000113
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	ISA	GO_REF:0000113
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183

Enzyme–Substrate Interactions ▾

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