RN149

Details:

UniProt Entry: Q8NC42
Gene: RNF149
Class: RING
Family: RING3
Protein length: 400
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8NC42
MAWRRREASV GARGVLALAL LALALCVPGA RGRALEWFSA VVNIEYVDPQ TNLTVWSVSE
SGRFGDSSPK EGAHGLVGVP WAPGGDLEGC APDTRFFVPE PGGRGAAPWV ALVARGGCTF
KDKVLVAARR NASAVVLYNE ERYGNITLPM SHAGTGNIVV IMISYPKGRE ILELVQKGIP
VTMTIGVGTR HVQEFISGQS VVFVAIAFIT MMIISLAWLI FYYIQRFLYT GSQIGSQSHR
KETKKVIGQL LLHTVKHGEK GIDVDAENCA VCIENFKVKD IIRILPCKHI FHRICIDPWL
LDHRTCPMCK LDVIKALGYW GEPGDVQEMP APESPPGRDP AANLSLALPD DDGSDDSSPP
SASPAESEPQ CDPSFKGDAG ENTALLEAGR SDSRHGGPIS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
89	192	Homologous_superfamily	PA domain superfamily	IPR046450	SSF52025
110	170	Domain	PA domain	IPR003137	PF02225
230	315	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
268	315	Domain	E3 ubiquitin-protein ligase RNF149, RING finger, H2 subclass	IPR042712	cd16804
268	310	Domain	Zinc finger, RING-type	IPR001841	PF13639
269	310	Domain	Zinc finger, RING-type	IPR001841	PS50089
269	309	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031647	regulation of protein stability	Biological Process	IEA	GO_REF:0000107
GO:0043409	negative regulation of MAPK cascade	Biological Process	IEA	GO_REF:0000107
GO:0071466	cellular response to xenobiotic stimulus	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005770	late endosome	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IBA	GO_REF:0000033
GO:0005794	Golgi apparatus	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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