KLH23

Details:

UniProt Entry: Q8NBE8
Gene: KLHL23
Class: Other E3 Components
Family: Adaptor
Protein length: 558
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8NBE8
MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN
YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL
SVKKACERFL VRHLDIDNCI GMHSFAEFHV CPELEKESRR ILCSKFKEVW QQEEFLEISL
EKFLFILSRK NLSVWKEEAI IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG
LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT EGLPMLNARY
YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA NMIKGVGNAT ACVLHDVIYV
IGGHCGYRGS CTYDKVQSYN SDINEWSLIT SSPHPEYGLC SVPFENKLYL VGGQTTITEC
YDPEQNEWRE IAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV
GNLPSAMRSH GCVCVYNV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	558	Family	BTB-kelch protein	IPR017096	PIRSF037037
5	135	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
12	132	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
15	141	Domain	Kelch-like protein 23, BTB/POZ domain	IPR030566	cd18252
32	133	Domain	BTB/POZ domain	IPR000210	PF00651
36	104	Domain	BTB/POZ domain	IPR000210	PS50097
36	134	Domain	BTB/POZ domain	IPR000210	SM00225
134	235	Domain	Kelch-like protein 23, BACK domain	IPR047068	cd18462
139	240	Domain	BTB/Kelch-associated	IPR011705	SM00875
139	237	Domain	BTB/Kelch-associated	IPR011705	PF07707
250	476	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
274	319	Repeat	Kelch repeat type 1	IPR006652	SM00612
275	554	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
275	303	Repeat	Kelch repeat type 1	IPR006652	PF01344
312	352	Repeat	Kelch repeat type 1	IPR006652	PF01344
321	369	Repeat	Kelch repeat type 1	IPR006652	SM00612
358	402	Repeat	Kelch repeat type 1	IPR006652	PF01344
370	416	Repeat	Kelch repeat type 1	IPR006652	SM00612
408	451	Repeat	Kelch repeat type 1	IPR006652	PF01344
417	466	Repeat	Kelch repeat type 1	IPR006652	SM00612
460	495	Repeat	Kelch repeat type 1	IPR006652	PF01344
467	508	Repeat	Kelch repeat type 1	IPR006652	SM00612
477	558	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
497	544	Repeat	Kelch repeat type 1	IPR006652	PF01344
509	557	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25036637
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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