ZBT38

Details:

UniProt Entry: Q8NAP3
Gene: ZBTB38
Class: RING
Family: RING6
Protein length: 1195
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 6e93, 6e94

Protein Sequence ▾

>Q8NAP3
MTVMSLSRDL KDDFHSDTVL SILNEQRIRG ILCDVTIIVE DTKFKAHSNV LAASSLYFKN
IFWSHTICIS SHVLELDDLK AEVFTEILNY IYSSTVVVKR QETVTDLAAA GKKLGISFLE
DLTDRNFSNS PGPYVFCITE KGVVKEEKNE KRHEEPAITN GPRITNAFSI IETENSNNMF
SPLDLRASFK KVSDSMRTAS LCLERTDVCH EAEPVRTLAE HSYAVSSVAE AYRSQPVREH
DGSSPGNTGK ENCEALAAKP KTCRKPKTFS IPQDSDSATE NIPPPPVSNL EVNQERSPQP
AAVLTRSKSP NNEGDVHFSR EDENQSSDVP GPPAAEVPPL VYNCSCCSKA FDSSTLLSAH
MQLHKPTQEP LVCKYCNKQF TTLNRLDRHE QICMRSSHMP IPGGNQRFLE NYPTIGQNGG
SFTGPEPLLS ENRIGEFSST GSTLPDTDHM VKFVNGQMLY SCVVCKRSYV TLSSLRRHAN
VHSWRRTYPC HYCNKVFALA EYRTRHEIWH TGERRYQCIF CLETFMTYYI LKNHQKSFHA
IDHRLSISKK TANGGLKPSV YPYKLYRLLP MKCKRAPYKS YRNSSYENAR ENSQMNESAP
GTYVVQNPHS SELPTLNFQD TVNTLTNSPA IPLETSACQD IPTSANVQNA EGTKWGEEAL
KMDLDNNFYS TEVSVSSTEN AVSSDLRAGD VPVLSLSNSS ENAASVISYS GSAPSVIVHS
SQFSSVIMHS NAIAAMTSSN HRAFSDPAVS QSLKDDSKPE PDKVGRFASR PKSIKEKKKT
TSHTRGEIPE ESNYVADPGG SLSKTTNIAE ETSKIETYIA KPALPGTSTN SNVAPLCQIT
VKIGNEAIVK RHILGSKLFY KRGRRPKYQM QEEPLPQGND PEPSGDSPLG LCQSECMEMS
EVFDDASDQD STDKPWRPYY NYKPKKKSRQ LKKMRKVNWR KEHGNRSPSH KCKYPAELDC
AVGKAPQDKP FEEEETKEMP KLQCELCDGD KAVGAGNQGR PHRHLTSRPY ACELCAKQFQ
SPSTLKMHMR CHTGEKPYQC KTCGRCFSVQ GNLQKHERIH LGLKEFVCQY CNKAFTLNET
LKIHERIHTG EKRYHCQFCF QRFLYLSTKR NHEQRHIREH NGKGYACFQC PKICKTAAAL
GMHQKKHLFK SPSQQEKIGD VCHENSNPLE NQHFIGSEDN DQKDNIQTGV ENVVL

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
9	133	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
12	122	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
23	126	Domain	BTB/POZ domain	IPR000210	PF00651
33	131	Domain	BTB/POZ domain	IPR000210	SM00225
33	100	Domain	BTB/POZ domain	IPR000210	PS50097
341	389	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
342	364	Domain	Zinc finger C2H2-type	IPR013087	SM00355
342	369	Domain	Zinc finger C2H2-type	IPR013087	PS50157
344	364	Domain	Zinc finger C2H2-type	IPR013087	PS00028
371	400	Domain	Zinc finger C2H2-type	IPR013087	PS50157
371	398	Domain	Zinc finger C2H2-type	IPR013087	SM00355
460	482	Domain	Zinc finger C2H2-type	IPR013087	PF00096
460	482	Domain	Zinc finger C2H2-type	IPR013087	SM00355
460	487	Domain	Zinc finger C2H2-type	IPR013087	PS50157
462	482	Domain	Zinc finger C2H2-type	IPR013087	PS00028
482	534	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
488	515	Domain	Zinc finger C2H2-type	IPR013087	PS50157
488	510	Domain	Zinc finger C2H2-type	IPR013087	SM00355
490	510	Domain	Zinc finger C2H2-type	IPR013087	PS00028
516	539	Domain	Zinc finger C2H2-type	IPR013087	SM00355
516	544	Domain	Zinc finger C2H2-type	IPR013087	PS50157
518	539	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1008	1060	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
1010	1032	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1010	1037	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1012	1032	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1038	1060	Domain	Zinc finger C2H2-type	IPR013087	PF00096
1038	1065	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1038	1060	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1040	1060	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1047	1103	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
1066	1093	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1066	1088	Domain	Zinc finger C2H2-type	IPR013087	PF00096
1066	1088	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1068	1088	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1094	1116	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1096	1116	Domain	Zinc finger C2H2-type	IPR013087	PS00028
1125	1152	Domain	Zinc finger C2H2-type	IPR013087	PS50157
1125	1147	Domain	Zinc finger C2H2-type	IPR013087	SM00355
1127	1147	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006355	regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0006275	regulation of DNA replication	Biological Process	IMP	PMID:24726359
GO:0006974	DNA damage response	Biological Process	IMP	PMID:24726359
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IDA	PMID:16354688
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0072562	blood microparticle	Cellular Component	HDA	PMID:22516433
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0008327	methyl-CpG binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003700	DNA-binding transcription factor activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:16354688
GO:0042803	protein homodimerization activity	Molecular Function	IDA	PMID:16354688

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.