DTX3

Details:

UniProt Entry: Q8N9I9
Gene: DTX3
Class: RING
Family: RING9
Protein length: 347
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8N9I9
MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI DGETSDIYVL
QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG ELMGCLALGG GGEHPEMHRA
GPPPLRAAPL LPPGARGLPP PPPPLPPPLP PRLREEAEEQ ESTCPICLGE IQNAKTLEKC
RHSFCEGCIT RALQVKKACP MCGRFYGQLV GNQPQNGRML VSKDATLLLP SYEKYGTIVI
QYVFPPGVQG AEHPNPGVRY PGTTRVAYLP DCPEGNKVLT LFRKAFDQRL TFTIGTSMTT
GRPNVITWND IHHKTSCTGG PQLFGYPDPT YLTRVQEELR AKGITDD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
8	345	Family	Deltex family	IPR039398	PTHR12622
148	208	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
164	202	Domain	Zinc finger, RING-type	IPR001841	PS50089
164	202	Domain	Zinc finger, RING-type	IPR001841	SM00184
180	189	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
210	345	Homologous_superfamily	Deltex, C-terminal domain superfamily	IPR039399	G3DSA:3.30.390.130
211	344	Domain	Deltex, C-terminal	IPR039396	PF18102
211	343	Domain	Deltex, C-terminal	IPR039396	cd09633

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007219	Notch signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0016746	acyltransferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0016874	ligase activity	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727

Enzyme–Substrate Interactions ▾


Q8N9I9	DTX3	Yes	No	No	No	—	No	E3-specific
Q04721	NOTC2	Yes	No	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8N9I9	DTX3	Yes	No	No	No	—	No	E3-specific
Q04721	NOTC2	Yes	No	No	No	—	No	E3-specific