RN152

Details:

UniProt Entry: Q8N8N0
Gene: RNF152
Class: RING
Family: RING4
Protein length: 203
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8N8N0
METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGVTKL
PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY MLPLPISKER ALLPGDMGCR
LLPGSQQKSV TVVTIPAEQQ PLQGGAPQEA VEEEQDRRGV VKSSTWSGVC TVILVACVLV
FLLGIVLHNM SCISKRFTVI SCG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	88	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
11	55	Domain	Zinc finger, RING-type	IPR001841	PF14634
11	55	Domain	E3 ubiquitin-protein ligase RNF152, RING finger domain	IPR033609	cd16548
12	55	Domain	Zinc finger, RING-type	IPR001841	PS50089
12	54	Domain	Zinc finger, RING-type	IPR001841	SM00184
67	203	Domain	E3 ubiquitin-protein ligase RNF152, C-terminal	IPR045744	PF19325

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0070534	protein K63-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0002181	cytoplasmic translation	Biological Process	IDA	PMID:34314702
GO:0009267	cellular response to starvation	Biological Process	IDA	PMID:24529379
GO:0031669	cellular response to nutrient levels	Biological Process	IDA	PMID:29236692
GO:0038202	TORC1 signaling	Biological Process	IDA	PMID:12087098
GO:0045947	negative regulation of translational initiation	Biological Process	IDA	PMID:22578813
GO:0045948	positive regulation of translational initiation	Biological Process	IDA	PMID:1922062
GO:0061462	protein localization to lysosome	Biological Process	IDA	PMID:31601708
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:12906785
GO:1904263	positive regulation of TORC1 signaling	Biological Process	IDA	PMID:29236692
GO:1990928	response to amino acid starvation	Biological Process	IDA	PMID:29590090
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:30514904
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000120
GO:0010508	positive regulation of autophagy	Biological Process	IBA	GO_REF:0000033
GO:0034198	cellular response to amino acid starvation	Biological Process	IBA	GO_REF:0000033
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:21203937
GO:0005764	lysosome	Cellular Component	IEA	GO_REF:0000043
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031090	organelle membrane	Cellular Component	IMP	PMID:25936802
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:21203937
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0031267	small GTPase binding	Molecular Function	IPI	PMID:25936802

Enzyme–Substrate Interactions ▾


Q15382	RHEB	Yes	Yes	No	No	—	No	E3-specific
Q7L523	RRAGA	Yes	Yes	No	No	—	No	E3-specific
O95859	TSN12	Yes	No	Yes	No	32296183	EBI-25167850	E3-specific

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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q15382	RHEB	Yes	Yes	No	No	—	No	E3-specific
Q7L523	RRAGA	Yes	Yes	No	No	—	No	E3-specific
O95859	TSN12	Yes	No	Yes	No	32296183	EBI-25167850	E3-specific