ZBTB2

Details:

UniProt Entry: Q8N680
Gene: ZBTB2
Class: RING
Family: RING6
Protein length: 514
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q8N680
MDLANHGLIL LQQLNAQREF GFLCDCTVAI GDVYFKAHKS VLASFSNYFK MLFVHQTSEC
VRLKPTDIQP DIFSYLLHLM YTGKMAPQLI DPVRLEQGIK FLHAYPLIQE ASLASQGAFS
HPDQVFPLAS SLYGIQIADH QLRQATKIAS APEKLGRDPR PQTSRISQEQ VPEASQLSQL
TSNLAQVNRT NMTPSDPLQT SLSPELVSTP VPPPPPGEET NLEASSSDEQ PASLTIAHVK
PSIMKRNGSF PKYYACHLCG RRFTLRSSLR EHLQIHTGVP FTSSQQGESR VPLTLCSNAA
DLGKDAMEVP EAGMISDSEL QHISDSPIID GQQQSETPPP SDIADIDNLE QADQEREVKR
RKYECTICGR KFIQKSHWRE HMYIHTGKPF KCSTCDKSFC RANQAARHVC LNQSIDTYTM
VDKQTLELCT FEEGSQMDNM LVQTNKPYKC NLCDKTFSTP NEVVKHSCQN QNSDVFALDE
GRSILLGSGD SEVTEPDHPV LASIKKEQET VLLD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	120	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
3	98	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
14	107	Domain	BTB/POZ domain	IPR000210	PF00651
24	89	Domain	BTB/POZ domain	IPR000210	PS50097
24	117	Domain	BTB/POZ domain	IPR000210	SM00225
250	279	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
254	278	Domain	Zinc finger C2H2-type	IPR013087	PS50157
254	276	Domain	Zinc finger C2H2-type	IPR013087	SM00355
254	276	Domain	Zinc finger C2H2-type	IPR013087	PF00096
256	276	Domain	Zinc finger C2H2-type	IPR013087	PS00028
360	408	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
363	385	Domain	Zinc finger C2H2-type	IPR013087	SM00355
363	390	Domain	Zinc finger C2H2-type	IPR013087	PS50157
363	385	Domain	Zinc finger C2H2-type	IPR013087	PF00096
365	385	Domain	Zinc finger C2H2-type	IPR013087	PS00028
390	410	Domain	Zinc finger C2H2-type	IPR013087	SM00355
444	470	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
448	468	Domain	Zinc finger C2H2-type	IPR013087	SM00355
448	466	Domain	Zinc finger C2H2-type	IPR013087	PS50157

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25609694
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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