LZTR1

Details:

UniProt Entry: Q8N653
Gene: LZTR1
Class: Other E3 Components
Family: Adaptor
Protein length: 840
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8N653
MAGPGSTGGQ IGAAALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET VHRWRRLPPC
DEFVGARRSK HTVVAYKDAI YVFGGDNGKT MLNDLLRFDV KDCSWCRAFT TGTPPAPRYH
HSAVVYGSSM FVFGGYTGDI YSNSNLKNKN DLFEYKFATG QWTEWKIEGR LPVARSAHGA
TVYSDKLWIF AGYDGNARLN DMWTIGLQDR ELTCWEEVAQ SGEIPPSCCN FPVAVCRDKM
FVFSGQSGAK ITNNLFQFEF KDKTWTRIPT EHLLRGSPPP PQRRYGHTMV AFDRHLYVFG
GAADNTLPNE LHCYDVDFQT WEVVQPSSDS EVGGAEVPER ACASEEVPTL TYEERVGFKK
SRDVFGLDFG TTSAKQPTQP ASELPSGRLF HAAAVISDAM YIFGGTVDNN IRSGEMYRFQ
FSCYPKCTLH EDYGRLWESR QFCDVEFVLG EKEECVQGHV AIVTARSRWL RRKITQARER
LAQKLEQEAA PVPREAPGVA AGGARPPLLH VAIREAEARP FEVLMQFLYT DKIKYPRKGH
VEDVLLIMDV YKLALSFQLC RLEQLCRQYI EASVDLQNVL VVCESAARLQ LSQLKEHCLN
FVVKESHFNQ VIMMKEFERL SSPLIVEIVR RKQQPPPRTP LDQPVDIGTS LIQDMKAYLE
GAGAEFCDIT LLLDGHPRPA HKAILAARSS YFEAMFRSFM PEDGQVNISI GEMVPSRQAF
ESMLRYIYYG EVNMPPEDSL YLFAAPYYYG FYNNRLQAYC KQNLEMNVTV QNVLQILEAA
DKTQALDMKR HCLHIIVHQF TKVSKLPTLR SLSQQLLLDI IDSLASHISD KQCAELGADI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
12	164	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
52	163	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
79	128	Repeat	Kelch repeat type 1	IPR006652	SM00612
129	185	Repeat	Kelch repeat type 1	IPR006652	SM00612
141	424	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
165	344	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
227	270	Repeat	Kelch repeat type 1	IPR006652	PF01344
239	294	Repeat	Kelch repeat type 1	IPR006652	SM00612
283	326	Repeat	Kelch repeat type 1	IPR006652	PF01344
295	339	Repeat	Kelch repeat type 1	IPR006652	SM00612
352	424	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
426	602	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
428	614	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
435	561	Domain	BTB/POZ domain	IPR000210	PF00651
443	537	Domain	BTB/POZ domain	IPR000210	PS50097
443	574	Domain	BTB/POZ domain	IPR000210	SM00225
646	798	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
663	798	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
665	762	Domain	BTB/POZ domain	IPR000210	PF00651
667	768	Domain	BTB/POZ domain	IPR000210	SM00225
667	736	Domain	BTB/POZ domain	IPR000210	PS50097

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0046580	negative regulation of Ras protein signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0055037	recycling endosome	Cellular Component	IEA	GO_REF:0000044
GO:0055038	recycling endosome membrane	Cellular Component	IDA	PMID:30442762
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:30442762
GO:0005515	protein binding	Molecular Function	IPI	PMID:19060904
GO:0031267	small GTPase binding	Molecular Function	IDA	PMID:30442762

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