RNF10

Details:

UniProt Entry: Q8N5U6
Gene: RNF10
Class: RING
Family: RING9
Protein length: 811
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8N5U6
MPLSSPNAAA TASDMDKNSG SNSSSASSGS SKGQQPPRSA SAGPAGESKP KSDGKNSSGS
KRYNRKRELS YPKNESFNNQ SRRSSSQKSK TFNKMPPQRG GGSSKLFSSS FNGGRRDEVA
EAQRAEFSPA QFSGPKKINL NHLLNFTFEP RGQTGHFEGS GHGSWGKRNK WGHKPFNKEL
FLQANCQFVV SEDQDYTAHF ADPDTLVNWD FVEQVRICSH EVPSCPICLY PPTAAKITRC
GHIFCWACIL HYLSLSEKTW SKCPICYSSV HKKDLKSVVA TESHQYVVGD TITMQLMKRE
KGVLVALPKS KWMNVDHPIH LGDEQHSQYS KLLLASKEQV LHRVVLEEKV ALEQQLAEEK
HTPESCFIEA AIQELKTREE ALSGLAGSRR EVTGVVAALE QLVLMAPLAK ESVFQPRKGV
LEYLSAFDEE TTEVCSLDTP SRPLALPLVE EEEAVSEPEP EGLPEACDDL ELADDNLKEG
TICTESSQQE PITKSGFTRL SSSPCYYFYQ AEDGQHMFLH PVNVRCLVRE YGSLERSPEK
ISATVVEIAG YSMSEDVRQR HRYLSHLPLT CEFSICELAL QPPVVSKETL EMFSDDIEKR
KRQRQKKARE ERRRERRIEI EENKKQGKYP EVHIPLENLQ QFPAFNSYTC SSDSALGPTS
TEGHGALSIS PLSRSPGSHA DFLLTPLSPT ASQGSPSFCV GSLEEDSPFP SFAQMLRVGK
AKADVWPKTA PKKDENSLVP PAPVDSDGES DNSDRVPVPS FQNSFSQAIE AAFMKLDTPA
TSDPLSEEKG GKKRKKQKQK LLFSTSVVHT K

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
21	806	Family	RING-finger protein Mag2/Rnf10	IPR039739	PTHR12983
211	299	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
224	266	Domain	Zinc finger, RING-type	IPR001841	PF13639
225	266	Domain	Zinc finger, RING-type	IPR001841	PS50089
225	266	Domain	Zinc finger, RING-type	IPR001841	SM00184
240	249	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010626	negative regulation of Schwann cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0031643	positive regulation of myelination	Biological Process	IEA	GO_REF:0000107
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0099527	postsynapse to nucleus signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:34348161
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:24105792
GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34348161
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0099147	extrinsic component of postsynaptic density membrane	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0022626	cytosolic ribosome	Cellular Component	IDA	PMID:34348161
GO:0000976	transcription cis-regulatory region binding	Molecular Function	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16335786
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:24105792

Enzyme–Substrate Interactions ▾

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