LNX2

Details:

UniProt Entry: Q8N448
Gene: LNX2
Class: RING
Family: RING9
Protein length: 690
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2vwr, 5din, 5e11, 5e1y, 5e21, 5e22, 7qct

Protein Sequence ▾

>Q8N448
MGTTSDEMVS VEQTSSSSLN PLCFECGQQH WTRENHLYNY QNEVDDDLVC HICLQPLLQP
LDTPCGHTFC YKCLRNFLQE KDFCPLDRKR LHFKLCKKSS ILVHKLLDKL LVLCPFSSVC
KDVMQRCDLE AHLKNRCPGA SHRRVALERR KTSRTQAEIE NENGPTLLDP AGTLSPEADC
LGTGAVPVER HLTSASLSTW SEEPGLDNPA FEESAGADTT QQPLSLPEGE ITTIEIHRSN
PYIQLGISIV GGNETPLINI VIQEVYRDGV IARDGRLLAG DQILQVNNYN ISNVSHNYAR
AVLSQPCNTL HLTVLRERRF GNRAHNHSDS NSPREEIFQV ALHKRDSGEQ LGIKLVRRTD
EPGVFILDLL EGGLAAQDGR LSSNDRVLAI NGHDLKYGTP ELAAQIIQAS GERVNLTIAR
PGKPQPGNTI REAGNHSSSS QHHTPPPYYS RPSSHKDLTQ CVTCQEKHIT VKKEPHESLG
MTVAGGRGSK SGELPIFVTS VPPHGCLARD GRIKRGDVLL NINGIDLTNL SHSEAVAMLK
ASAASPAVAL KALEVQIVEE ATQNAEEQPS TFSENEYDAS WSPSWVMWLG LPSTLHSCHD
IVLRRSYLGS WGFSIVGGYE ENHTNQPFFI KTIVLGTPAY YDGRLKCGDM IVAVNGLSTV
GMSHSALVPM LKEQRNKVTL TVICWPGSLV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
18	147	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
50	87	Domain	Zinc finger, RING-type	IPR001841	SM00184
50	88	Domain	Zinc finger, RING-type	IPR001841	PS50089
65	74	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
213	320	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
224	317	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
233	318	Domain	PDZ domain	IPR001478	PS50106
236	315	Domain	PDZ domain	IPR001478	PF00595
243	318	Domain	PDZ domain	IPR001478	SM00228
328	426	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
329	420	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
339	422	Domain	PDZ domain	IPR001478	PS50106
340	418	Domain	PDZ domain	IPR001478	PF00595
349	422	Domain	PDZ domain	IPR001478	SM00228
433	554	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
440	552	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
468	554	Domain	PDZ domain	IPR001478	PS50106
469	549	Domain	PDZ domain	IPR001478	PF00595
477	556	Domain	PDZ domain	IPR001478	SM00228
568	685	Homologous_superfamily	PDZ superfamily	IPR036034	SSF50156
592	686	Homologous_superfamily	PDZ superfamily	IPR036034	G3DSA:2.30.42.10
600	682	Domain	PDZ domain	IPR001478	PS50106
604	682	Domain	PDZ domain	IPR001478	PF00595
609	686	Domain	PDZ domain	IPR001478	SM00228

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0030182	neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0061351	neural precursor cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0007399	nervous system development	Biological Process	IEA	GO_REF:0000117
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000107
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:21516116
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0030165	PDZ domain binding	Molecular Function	IEA	GO_REF:0000120
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾


Q9UKL4	CXD2	Yes	No	No	No	—	No	Cluster-specific

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