FBXW8

Details:

UniProt Entry: Q8N3Y1
Gene: FBXW8
Class: Other E3 Components
Family: Receptor
Protein length: 598
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8N3Y1
MDDYSLDEFR RRWQEELAQA QAPKKRRRPE AAERRARRPE VGSGRGEQAS GDPALAQRLL
EGAGRPPAAR ATRAEGQDVA SRSRSPLARE GAGGGEQLVD QLIRDLNEMN DVPFFDIQLP
YELAINIFQY LDRKELGRCA QVSKTWKVIA EDEVLWYRLC QQEGHLPDSS ISDYSCWKLI
FQECRAKEHM LRTNWKNRKG AVSELEHVPD TVLCDVHSHD GVVIAGYTSG DVRVWDTRTW
DYVAPFLESE DEEDEPGMQP NVSFVRINSS LAVAAYEDGF LNIWDLRTGK YPVHRFEHDA
RIQALALSQD DATVATASAF DVVMLSPNEE GYWQIAAEFE VPKLVQYLEI VPETRRYPVA
VAAAGDLMYL LKAEDSARTL LYAHGPPVTC LDVSANQVAF GVQGLGWVYE GSKILVYSLE
AGRRLLKLGN VLRDFTCVNL SDSPPNLMVS GNMDGRVRIH DLRSGNIALS LSAHQLRVSA
VQMDDWKIVS GGEEGLVSVW DYRMNQKLWE VYSGHPVQHI SFSSHSLITA NVPYQTVMRN
ADLDSFTTHR RHRGLIRAYE FAVDQLAFQS PLPVCRSSCD AMATHYYDLA LAFPYNHV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
113	159	Domain	F-box domain	IPR001810	PS50181
118	202	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
118	161	Domain	F-box domain	IPR001810	PF12937
119	159	Domain	F-box domain	IPR001810	SM00256
195	331	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
198	236	Repeat	WD40 repeat	IPR001680	SM00320
207	526	Homologous_superfamily	Quinoprotein alcohol dehydrogenase-like superfamily	IPR011047	SSF50998
239	285	Repeat	WD40 repeat	IPR001680	SM00320
289	326	Repeat	WD40 repeat	IPR001680	SM00320
361	583	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
425	461	Repeat	WD40 repeat	IPR001680	SM00320
464	501	Repeat	WD40 repeat	IPR001680	SM00320
471	510	Repeat	WD40 repeat	IPR001680	PS50082

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:17636018
GO:0008286	insulin receptor signaling pathway	Biological Process	IDA	PMID:38056462
GO:0045727	positive regulation of translation	Biological Process	IMP	PMID:28106072
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process	IDA	PMID:18498745
GO:0060716	labyrinthine layer blood vessel development	Biological Process	IEA	GO_REF:0000107
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:39032648
GO:0007030	Golgi organization	Biological Process	ISS	GO_REF:0000024
GO:0008283	cell population proliferation	Biological Process	IDA	PMID:24362026
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:17205132
GO:0050775	positive regulation of dendrite morphogenesis	Biological Process	ISS	GO_REF:0000024
GO:0060271	cilium assembly	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:1990393	3M complex	Cellular Component	IDA	PMID:24793695
GO:0005814	centriole	Cellular Component	IBA	GO_REF:0000033
GO:0036064	ciliary basal body	Cellular Component	IBA	GO_REF:0000033
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0031467	Cul7-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:15070733
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000107

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