FXL14

Details:

UniProt Entry: Q8N1E6
Gene: FBXL14
Class: Other E3 Components
Family: Receptor
Protein length: 418
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8N1E6
METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA KLHLRRANPS
LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC YNLTDNGLGH AFVQEIGSLR
ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL GGCSNITNTG LLLIAWGLQR LKSLNLRSCR
HLSDVGIGHL AGMTRSAAEG CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG
ISDAGLLHLS HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI
AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL IAEHLSQLTG
IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKEA RGDFSPLFTV RTRGSSRR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	254	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
3	48	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
10	46	Domain	F-box domain	IPR001810	PF12937
89	114	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
116	141	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
118	135	Repeat	Leucine-rich repeat	IPR001611	PF13516
142	167	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
168	193	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
169	191	Repeat	Leucine-rich repeat	IPR001611	PF13516
201	226	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
227	252	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
230	250	Repeat	Leucine-rich repeat	IPR001611	PF13516
253	277	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
254	275	Repeat	Leucine-rich repeat	IPR001611	PF13516
255	413	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
278	303	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
304	328	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
329	354	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
332	352	Repeat	Leucine-rich repeat	IPR001611	PF13516
355	380	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:19955572
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:19955572
GO:0005515	protein binding	Molecular Function	IPI	PMID:19955572

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