BCL6B

Details:

UniProt Entry: Q8N143
Gene: BCL6B
Class: RING
Family: RING6
Protein length: 479
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q8N143
MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS
GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM
EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG
PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS
SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF
FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI
CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR
FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
13	138	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
15	132	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
28	134	Domain	BTB/POZ domain	IPR000210	PF00651
38	105	Domain	BTB/POZ domain	IPR000210	PS50097
38	135	Domain	BTB/POZ domain	IPR000210	SM00225
326	378	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
328	355	Domain	Zinc finger C2H2-type	IPR013087	PS50157
328	350	Domain	Zinc finger C2H2-type	IPR013087	SM00355
330	350	Domain	Zinc finger C2H2-type	IPR013087	PS00028
356	383	Domain	Zinc finger C2H2-type	IPR013087	PS50157
356	378	Domain	Zinc finger C2H2-type	IPR013087	PF00096
356	378	Domain	Zinc finger C2H2-type	IPR013087	SM00355
358	378	Domain	Zinc finger C2H2-type	IPR013087	PS00028
365	421	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
384	411	Domain	Zinc finger C2H2-type	IPR013087	PS50157
384	406	Domain	Zinc finger C2H2-type	IPR013087	SM00355
386	406	Domain	Zinc finger C2H2-type	IPR013087	PS00028
406	458	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
412	439	Domain	Zinc finger C2H2-type	IPR013087	PS50157
412	434	Domain	Zinc finger C2H2-type	IPR013087	SM00355
412	434	Domain	Zinc finger C2H2-type	IPR013087	PF00096
414	434	Domain	Zinc finger C2H2-type	IPR013087	PS00028
440	468	Domain	Zinc finger C2H2-type	IPR013087	PS50157
440	463	Domain	Zinc finger C2H2-type	IPR013087	SM00355
442	463	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000107
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0042092	type 2 immune response	Biological Process	IBA	GO_REF:0000033
GO:0042127	regulation of cell population proliferation	Biological Process	IBA	GO_REF:0000033
GO:0045595	regulation of cell differentiation	Biological Process	IBA	GO_REF:0000033
GO:0050727	regulation of inflammatory response	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000107
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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