RN168

Details:

UniProt Entry: Q8IYW5
Gene: RNF168
Class: RING
Family: RING9
Protein length: 571
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3l11, 4gb0, 5xis, 5xit, 5xiu, 5ydk

Protein Sequence ▾

>Q8IYW5
MALPKDAIPS LSECQCGICM EILVEPVTLP CNHTLCKPCF QSTVEKASLC CPFCRRRVSS
WTRYHTRRNS LVNVELWTII QKHYPRECKL RASGQESEEV ADDYQPVRLL SKPGELRREY
EEEISKVAAE RRASEEEENK ASEEYIQRLL AEEEEEEKRQ AEKRRRAMEE QLKSDEELAR
KLSIDINNFC EGSISASPLN SRKSDPVTPK SEKKSKNKQR NTGDIQKYLT PKSQFGSASH
SEAVQEVRKD SVSKDIDSSD RKSPTGQDTE IEDMPTLSPQ ISLGVGEQGA DSSIESPMPW
LCACGAEWYH EGNVKTRPSN HGKELCVLSH ERPKTRVPYS KETAVMPCGR TESGCAPTSG
VTQTNGNNTG ETENEESCLL ISKEISKRKN QESSFEAVKD PCFSAKRRKV SPESSPDQEE
TEINFTQKLI DLEHLLFERH KQEEQDRLLA LQLQKEVDKE QMVPNRQKGS PDEYHLRATS
SPPDKVLNGQ RKNPKDGNFK RQTHTKHPTP ERGSRDKNRQ VSLKMQLKQS VNRRKMPNST
RDHCKVSKSA HSLQPSISQK SVFQMFQRCT K

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	113	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
1	568	Family	E3 ubiquitin-protein ligase RNF168	IPR034725	MF_03066
16	54	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	55	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006259	DNA metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0009314	response to radiation	Biological Process	IEA	GO_REF:0000117
GO:0000077	DNA damage checkpoint signaling	Biological Process	IDA	PMID:31135337
GO:0006302	double-strand break repair	Biological Process	IDA	PMID:11390642
GO:0097680	double-strand break repair via classical nonhomologous end joining	Biological Process	IDA	PMID:27153538
GO:0006303	double-strand break repair via nonhomologous end joining	Biological Process	IDA	PMID:27153538
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:22373579
GO:0010212	response to ionizing radiation	Biological Process	IEA	GO_REF:0000104
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0034244	negative regulation of transcription elongation by RNA polymerase II	Biological Process	IMP	PMID:20550933
GO:0036297	interstrand cross-link repair	Biological Process	TAS	PMID:22705371
GO:0040029	epigenetic regulation of gene expression	Biological Process	IMP	PMID:20550933
GO:0045190	isotype switching	Biological Process	ISS	GO_REF:0000024
GO:0045739	positive regulation of DNA repair	Biological Process	IEA	GO_REF:0000104
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:22266820
GO:0140861	DNA repair-dependent chromatin remodeling	Biological Process	IDA	PMID:19203578
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:1902494	catalytic complex	Cellular Component	IEA	GO_REF:0000117
GO:0035861	site of double-strand break	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000104
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:24217620
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000104
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:15231748
GO:0031491	nucleosome binding	Molecular Function	IBA	GO_REF:0000033
GO:0042393	histone binding	Molecular Function	IEA	GO_REF:0000104
GO:0043130	ubiquitin binding	Molecular Function	IEA	GO_REF:0000104
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Molecular Function	IDA	PMID:19500350
GO:0140852	histone ubiquitin ligase activity	Molecular Function	IDA	PMID:19500350
GO:0140858	histone H2AK15 ubiquitin ligase activity	Molecular Function	IMP	PMID:23760478

Enzyme–Substrate Interactions ▾


O75164	KDM4A	Yes	Yes	No	No	—	No	Cluster-specific
P08134	RHOC	Yes	No	No	No	—	No	Cluster-specific
Q9P0M6	H2AW	Yes	No	No	No	—	No	E3-specific
Q8IYW5	RN168	Yes	No	No	No	—	No	E3-specific

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O75164	KDM4A	Yes	Yes	No	No	—	No	Cluster-specific
P08134	RHOC	Yes	No	No	No	—	No	Cluster-specific
Q9P0M6	H2AW	Yes	No	No	No	—	No	E3-specific
Q8IYW5	RN168	Yes	No	No	No	—	No	E3-specific