TRI22

Details:

UniProt Entry: Q8IYM9
Gene: TRIM22
Class: RING
Family: RING5
Protein length: 498
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8IYM9
MDFSVKVDIE KEVTCPICLE LLTEPLSLDC GHSFCQACIT AKIKESVIIS RGESSCPVCQ
TRFQPGNLRP NRHLANIVER VKEVKMSPQE GQKRDVCEHH GKKLQIFCKE DGKVICWVCE
LSQEHQGHQT FRINEVVKEC QEKLQVALQR LIKEDQEAEK LEDDIRQERT AWKNYIQIER
QKILKGFNEM RVILDNEEQR ELQKLEEGEV NVLDNLAAAT DQLVQQRQDA STLISDLQRR
LRGSSVEMLQ DVIDVMKRSE SWTLKKPKSV SKKLKSVFRV PDLSGMLQVL KELTDVQYYW
VDVMLNPGSA TSNVAISVDQ RQVKTVRTCT FKNSNPCDFS AFGVFGCQYF SSGKYYWEVD
VSGKIAWILG VHSKISSLNK RKSSGFAFDP SVNYSKVYSR YRPQYGYWVI GLQNTCEYNA
FEDSSSSDPK VLTLFMAVPP CRIGVFLDYE AGIVSFFNVT NHGALIYKFS GCRFSRPAYP
YFNPWNCLVP MTVCPPSS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	91	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
15	57	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
15	59	Domain	Zinc finger, RING-type	IPR001841	SM00184
15	60	Domain	Zinc finger, RING-type	IPR001841	PS50089
30	39	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
92	133	Domain	B-box-type zinc finger	IPR000315	SM00336
92	133	Domain	B-box-type zinc finger	IPR000315	PS50119
93	130	Domain	B-box-type zinc finger	IPR000315	PF00643
283	498	Domain	B30.2/SPRY domain	IPR001870	PS50188
290	498	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
294	496	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
299	496	Domain	TRIM22, PRY/SPRY domain	IPR035827	cd15824
299	316	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
337	361	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
352	497	Domain	SPRY domain	IPR003877	SM00449
354	484	Domain	SPRY domain	IPR003877	PF00622
434	458	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
466	484	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0080090	regulation of primary metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0140374	antiviral innate immune response	Biological Process	IDA	PMID:27992402
GO:0002230	positive regulation of defense response to virus by host	Biological Process	IDA	PMID:36159777
GO:0006355	regulation of DNA-templated transcription	Biological Process	TAS	PMID:7797467
GO:0006955	immune response	Biological Process	TAS	PMID:7797467
GO:0009615	response to virus	Biological Process	TAS	PMID:7797467
GO:0010508	positive regulation of autophagy	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0032880	regulation of protein localization	Biological Process	IBA	GO_REF:0000033
GO:0043123	positive regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0051607	defense response to virus	Biological Process	IEA	GO_REF:0000043
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:36159777
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005794	Golgi apparatus	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1031716
GO:0015030	Cajal body	Cellular Component	IEA	GO_REF:0000044
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23077300
GO:0003714	transcription corepressor activity	Molecular Function	TAS	PMID:7797467
GO:0005515	protein binding	Molecular Function	IPI	PMID:25127057
GO:0019901	protein kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IPI	PMID:25127057
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q8IYM9	TRI22	Yes	Yes	No	No	—	No	E3-specific

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