SLX4

Details:

UniProt Entry: Q8IY92
Gene: SLX4
Class: Other E3 Components
Family: Adaptor
Protein length: 1834
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8IY92
MKLSVNEAQL GFYLGSLSHL SACPGIDPRS SEDQPESLKT GQMMDESDED FKELCASFFQ
RVKKHGIKEV SGERKTQKAA SNGTQIRSKL KRTKQTATKT KTLQGPAEKK PPSGSQAPRT
KKQRVTKWQA SEPAHSVNGE GGVLASAPDP PVLRETAQNT QTGNQQEPSP NLSREKTREN
VPNSDSQPPP SCLTTAVPSP SKPRTAQLVL QRMQQFKRAD PERLRHASEE CSLEAAREEN
VPKDPQEEMM AGNVYGLGPP APESDAAVAL TLQQEFARVG ASAHDDSLEE KGLFFCQICQ
KNLSAMNVTR REQHVNRCLD EAEKTLRPSV PQIPECPICG KPFLTLKSRT SHLKQCAVKM
EVGPQLLLQA VRLQTAQPEG SSSPPMFSFS DHSRGLKRRG PTSKKEPRKR RKVDEAPSED
LLVAMALSRS EMEPGAAVPA LRLESAFSER IRPEAENKSR KKKPPVSPPL LLVQDSETTG
RQIEDRVALL LSEEVELSST PPLPASRILK EGWERAGQCP PPPERKQSFL WEGSALTGAW
AMEDFYTARL VPPLVPQRPA QGLMQEPVPP LVPPEHSELS ERRSPALHGT PTAGCGSRGP
SPSASQREHQ ALQDLVDLAR EGLSASPWPG SGGLAGSEGT AGLDVVPGGL PLTGFVVPSQ
DKHPDRGGRT LLSLGLLVAD FGAMVNNPHL SDVQFQTDSG EVLYAHKFVL YARCPLLIQY
VNNEGFSAVE DGVLTQRVLL GDVSTEAART FLHYLYTADT GLPPGLSSEL SSLAHRFGVS
ELVHLCEQVP IATDSEGKPW EEKEAENCES RAENFQELLR SMWADEEEEA ETLLKSKDHE
EDQENVNEAE MEEIYEFAAT QRKLLQEERA AGAGEDADWL EGGSPVSGQL LAGVQVQKQW
DKVEEMEPLE PGRDEAATTW EKMGQCALPP PQGQHSGARG AEAPEQEAPE EALGHSSCSS
PSRDCQAERK EGSLPHSDDA GDYEQLFSST QGEISEPSQI TSEPEEQSGA VRERGLEVSH
RLAPWQASPP HPCRFLLGPP QGGSPRGSHH TSGSSLSTPR SRGGTSQVGS PTLLSPAVPS
KQKRDRSILT LSKEPGHQKG KERRSVLECR NKGVLMFPEK SPSIDLTQSN PDHSSSRSQK
SSSKLNEEDE VILLLDSDEE LELEQTKMKS ISSDPLEEKK ALEISPRSCE LFSIIDVDAD
QEPSQSPPRS EAVLQQEDEG ALPENRGSLG RRGAPWLFCD RESSPSEAST TDTSWLVPAT
PLASRSRDCS SQTQISSLRS GLAVQAVTQH TPRASVGNRE GNEVAQKFSV IRPQTPPPQT
PSSCLTPVSP GTSDGRRQGH RSPSRPHPGG HPHSSPLAPH PISGDRAHFS RRFLKHSPPG
PSFLNQTPAG EVVEVGDSDD EQEVASHQAN RSPPLDSDPP IPIDDCCWHM EPLSPIPIDH
WNLERTGPLS TSSPSRRMNE AADSRDCRSP GLLDTTPIRG SCTTQRKLQE KSSGAGSLGN
SRPSFLNSAL WDVWDGEEQR PPETPPPAQM PSAGGAQKPE GLETPKGANR KKNLPPKVPI
TPMPQYSIME TPVLKKELDR FGVRPLPKRQ MVLKLKEIFQ YTHQTLDSDS EDESQSSQPL
LQAPHCQTLA SQTYKPSRAG VHAQQEATTG PGAHRPKGPA KTKGPRHQRK HHESITPPSR
SPTKEAPPGL NDDAQIPASQ ESVATSVDGS DSSLSSQSSS SCEFGAAFES AGEEEGEGEV
SASQAAVQAA DTDEALRCYI RSKPALYQKV LLYQPFELRE LQAELRQNGL RVSSRRLLDF
LDTHCITFTT AATRREKLQG RRRQPRGKKK VERN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
293	323	Domain	Rad18, zinc finger UBZ4-type	IPR006642	PS51908
333	361	Domain	Rad18, zinc finger UBZ4-type	IPR006642	PS51908
665	796	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
678	788	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
684	789	Domain	BTB/POZ domain	IPR000210	PF00651
691	764	Domain	BTB/POZ domain	IPR000210	PS50097
691	794	Domain	BTB/POZ domain	IPR000210	SM00225
1754	1810	Family	Structure-specific endonuclease subunit Slx4	IPR018574	PF09494

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0072429	response to intra-S DNA damage checkpoint signaling	Biological Process	IMP	PMID:23361013
GO:0000712	resolution of meiotic recombination intermediates	Biological Process	IBA	GO_REF:0000033
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IMP	PMID:19595721
GO:0006260	DNA replication	Biological Process	IEA	GO_REF:0000002
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000120
GO:0006289	nucleotide-excision repair	Biological Process	IMP	PMID:19596236
GO:0006310	DNA recombination	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing	Biological Process	IMP	PMID:19595721
GO:0032206	positive regulation of telomere maintenance	Biological Process	IEA	GO_REF:0000117
GO:0061820	telomeric D-loop disassembly	Biological Process	IMP	PMID:24012755
GO:0090656	t-circle formation	Biological Process	ISS	GO_REF:0000024
GO:1904357	negative regulation of telomere maintenance via telomere lengthening	Biological Process	IMP	PMID:24012755
GO:1904431	positive regulation of t-circle formation	Biological Process	ISS	GO_REF:0000024
GO:0000781	chromosome, telomeric region	Cellular Component	IDA	PMID:19596235
GO:0048476	Holliday junction resolvase complex	Cellular Component	IDA	PMID:19595721
GO:0070522	ERCC4-ERCC1 complex	Cellular Component	IDA	PMID:19595721
GO:0000785	chromatin	Cellular Component	IDA	PMID:19596235
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0033557	Slx1-Slx4 complex	Cellular Component	IEA	GO_REF:0000002
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:19595721
GO:0008047	enzyme activator activity	Molecular Function	IDA	PMID:19596235
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

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