KBTB2

Details:

UniProt Entry: Q8IY47
Gene: KBTBD2
Class: Other E3 Components
Family: Adaptor
Protein length: 623
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8IY47
MSTQDERQIN TEYAVSLLEQ LKLFYEQQLF TDIVLIVEGT EFPCHKMVLA TCSSYFRAMF
MSGLSESKQT HVHLRNVDAA TLQIIITYAY TGNLAMNDST VEQLYETACF LQVEDVLQRC
REYLIKKINA ENCVRLLSFA DLFSCEELKQ SAKRMVEHKF TAVYHQDAFM QLSHDLLIDI
LSSDNLNVEK EETVREAAML WLEYNTESRS QYLSSVLSQI RIDALSEVTQ RAWFQGLPPN
DKSVVVQGLY KSMPKFFKPR LGMTKEEMMI FIEASSENPC SLYSSVCYSP QAEKVYKLCS
PPADLHKVGT VVTPDNDIYI AGGQVPLKNT KTNHSKTSKL QTAFRTVNCF YWFDAQQNTW
FPKTPMLFVR IKPSLVCCEG YIYAIGGDSV GGELNRRTVE RYDTEKDEWT MVSPLPCAWQ
WSAAVVVHDC IYVMTLNLMY CYFPRSDSWV EMAMRQTSRS FASAAAFGDK IFYIGGLHIA
TNSGIRLPSG TVDGSSVTVE IYDVNKNEWK MAANIPAKRY SDPCVRAVVI SNSLCVFMRE
THLNERAKYV TYQYDLELDR WSLRQHISER VLWDLGRDFR CTVGKLYPSC LEESPWKPPT
YLFSTDGTEE FELDGEMVAL PPV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	573	Family	BTB-kelch protein	IPR017096	PIRSF037037
2	129	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
5	137	Domain	Kelch repeat and BTB domain-containing protein 2, BTB/POZ domain	IPR030586	cd18270
12	126	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
24	127	Domain	BTB/POZ domain	IPR000210	PF00651
31	98	Domain	BTB/POZ domain	IPR000210	PS50097
31	128	Domain	BTB/POZ domain	IPR000210	SM00225
128	223	Domain	Kelch repeat and BTB domain-containing protein 2, BACK domain	IPR047074	cd18479
133	229	Domain	BTB/Kelch-associated	IPR011705	PF07707
133	235	Domain	BTB/Kelch-associated	IPR011705	SM00875
257	571	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
267	573	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
317	380	Repeat	Kelch repeat type 1	IPR006652	SM00612
373	416	Repeat	Kelch repeat type 1	IPR006652	PF01344
381	429	Repeat	Kelch repeat type 1	IPR006652	SM00612
430	469	Repeat	Kelch repeat type 1	IPR006652	SM00612
470	532	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006006	glucose metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0006629	lipid metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0032868	response to insulin	Biological Process	IEA	GO_REF:0000107
GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0032869	cellular response to insulin stimulus	Biological Process	IDA	PMID:27708159
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:27708159
GO:1900076	regulation of cellular response to insulin stimulus	Biological Process	IC	PMID:27708159
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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