KLHL7

Details:

UniProt Entry: Q8IXQ5
Gene: KLHL7
Class: Other E3 Components
Family: Adaptor
Protein length: 586
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q8IXQ5
MAASGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ KTLCDVILMV QERKIPAHRV
VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA
ANQYQIEPVK KMCVDFLKEQ VDASNCLGIS VLAECLDCPE LKATADDFIH QHFTEVYKTD
EFLQLDVKRV THLLNQDTLT VRAEDQVYDA AVRWLKYDEP NRQPFMVDIL AKVRFPLISK
NFLSKTVQAE PLIQDNPECL KMVISGMRYH LLSPEDREEL VDGTRPRRKK HDYRIALFGG
SQPQSCRYFN PKDYSWTDIR CPFEKRRDAA CVFWDNVVYI LGGSQLFPIK RMDCYNVVKD
SWYSKLGPPT PRDSLAACAA EGKIYTSGGS EVGNSALYLF ECYDTRTESW HTKPSMLTQR
CSHGMVEANG LIYVCGGSLG NNVSGRVLNS CEVYDPATET WTELCPMIEA RKNHGLVFVK
DKIFAVGGQN GLGGLDNVEY YDIKLNEWKM VSPMPWKGVT VKCAAVGSIV YVLAGFQGVG
RLGHILEYNT ETDKWVANSK VRAFPVTSCL ICVVDTCGAN EETLET

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	580	Family	BTB-kelch protein	IPR017096	PIRSF037037
10	170	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
23	148	Domain	Kelch-like protein 7, BTB/POZ domain	IPR030599	cd18237
30	139	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
34	140	Domain	BTB/POZ domain	IPR000210	PF00651
44	111	Domain	BTB/POZ domain	IPR000210	PS50097
44	141	Domain	BTB/POZ domain	IPR000210	SM00225
140	237	Domain	Kelch-like protein 7, BACK domain	IPR047060	cd18447
146	248	Domain	BTB/Kelch-associated	IPR011705	PF07707
146	248	Domain	BTB/Kelch-associated	IPR011705	SM00875
282	586	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
298	558	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
337	382	Repeat	Kelch repeat type 1	IPR006652	SM00612
374	416	Repeat	Kelch repeat type 1	IPR006652	PF01344
383	430	Repeat	Kelch repeat type 1	IPR006652	SM00612
420	467	Repeat	Kelch repeat type 1	IPR006652	PF01344
431	481	Repeat	Kelch repeat type 1	IPR006652	SM00612
470	515	Repeat	Kelch repeat type 1	IPR006652	PF01344
482	528	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000054
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA	PMID:27392078
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:21145461
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:21828050
GO:0042803	protein homodimerization activity	Molecular Function	IDA	PMID:21828050
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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