UBR2

Details:

UniProt Entry: Q8IWV8
Gene: UBR2
Class: RING
Family: RING10
Protein length: 1755
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3ny2, 3ny3, 5tda, 5tdb, 5tdd, 5um3

Protein Sequence ▾

>Q8IWV8
MASELEPEVQ AIDRSLLECS AEEIAGKWLQ ATDLTREVYQ HLAHYVPKIY CRGPNPFPQK
EDMLAQHVLL GPMEWYLCGE DPAFGFPKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT
CVLCMECFLG SIHRDHRYRM TTSGGGGFCD CGDTEAWKEG PYCQKHELNT SEIEEEEDPL
VHLSEDVIAR TYNIFAITFR YAVEILTWEK ESELPADLEM VEKSDTYYCM LFNDEVHTYE
QVIYTLQKAV NCTQKEAIGF ATTVDRDGRR SVRYGDFQYC EQAKSVIVRN TSRQTKPLKV
QVMHSSIVAH QNFGLKLLSW LGSIIGYSDG LRRILCQVGL QEGPDGENSS LVDRLMLSDS
KLWKGARSVY HQLFMSSLLM DLKYKKLFAV RFAKNYQQLQ RDFMEDDHER AVSVTALSVQ
FFTAPTLARM LITEENLMSI IIKTFMDHLR HRDAQGRFQF ERYTALQAFK FRRVQSLILD
LKYVLISKPT EWSDELRQKF LEGFDAFLEL LKCMQGMDPI TRQVGQHIEM EPEWEAAFTL
QMKLTHVISM MQDWCASDEK VLIEAYKKCL AVLMQCHGGY TDGEQPITLS ICGHSVETIR
YCVSQEKVSI HLPVSRLLAG LHVLLSKSEV AYKFPELLPL SELSPPMLIE HPLRCLVLCA
QVHAGMWRRN GFSLVNQIYY YHNVKCRREM FDKDVVMLQT GVSMMDPNHF LMIMLSRFEL
YQIFSTPDYG KRFSSEITHK DVVQQNNTLI EEMLYLIIML VGERFSPGVG QVNATDEIKR
EIIHQLSIKP MAHSELVKSL PEDENKETGM ESVIEAVAHF KKPGLTGRGM YELKPECAKE
FNLYFYHFSR AEQSKAEEAQ RKLKRQNRED TALPPPVLPP FCPLFASLVN ILQSDVMLCI
MGTILQWAVE HNGYAWSESM LQRVLHLIGM ALQEEKQHLE NVTEEHVVTF TFTQKISKPG
EAPKNSPSIL AMLETLQNAP YLEVHKDMIR WILKTFNAVK KMRESSPTSP VAETEGTIME
ESSRDKDKAE RKRKAEIARL RREKIMAQMS EMQRHFIDEN KELFQQTLEL DASTSAVLDH
SPVASDMTLT ALGPAQTQVP EQRQFVTCIL CQEEQEVKVE SRAMVLAAFV QRSTVLSKNR
SKFIQDPEKY DPLFMHPDLS CGTHTSSCGH IMHAHCWQRY FDSVQAKEQR RQQRLRLHTS
YDVENGEFLC PLCECLSNTV IPLLLPPRNI FNNRLNFSDQ PNLTQWIRTI SQQIKALQFL
RKEESTPNNA STKNSENVDE LQLPEGFRPD FRPKIPYSES IKEMLTTFGT ATYKVGLKVH
PNEEDPRVPI MCWGSCAYTI QSIERILSDE DKPLFGPLPC RLDDCLRSLT RFAAAHWTVA
SVSVVQGHFC KLFASLVPND SHEELPCILD IDMFHLLVGL VLAFPALQCQ DFSGISLGTG
DLHIFHLVTM AHIIQILLTS CTEENGMDQE NPPCEEESAV LALYKTLHQY TGSALKEIPS
GWHLWRSVRA GIMPFLKCSA LFFHYLNGVP SPPDIQVPGT SHFEHLCSYL SLPNNLICLF
QENSEIMNSL IESWCRNSEV KRYLEGERDA IRYPRESNKL INLPEDYSSL INQASNFSCP
KSGGDKSRAP TLCLVCGSLL CSQSYCCQTE LEGEDVGACT AHTYSCGSGV GIFLRVRECQ
VLFLAGKTKG CFYSPPYLDD YGETDQGLRR GNPLHLCKER FKKIQKLWHQ HSVTEEIGHA
QEANQTLVGI DWQHL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
27	1748	Family	E3 ubiquitin-protein ligase UBR1-like	IPR039164	PTHR21497
97	167	Domain	Zinc finger, UBR-type	IPR003126	SM00396
97	168	Domain	Zinc finger, UBR-type	IPR003126	PS51157
99	166	Domain	Zinc finger, UBR-type	IPR003126	PF02207
207	306	Homologous_superfamily	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like	IPR014719	G3DSA:3.30.1390.10
221	303	Homologous_superfamily	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like	IPR014719	SSF54736
223	300	Domain	Adaptor protein ClpS, core	IPR003769	PF02617
772	868	Homologous_superfamily	E3 ubiquitin-protein ligase ELL-like	IPR042065	G3DSA:1.10.10.2670
777	860	Homologous_superfamily	Winged helix DNA-binding domain superfamily	IPR036390	SSF46785
1311	1729	Domain	E3 ubiquitin-protein ligase UBR-like, C-terminal	IPR044046	PF18995

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0007141	male meiosis I	Biological Process	IEA	GO_REF:0000107
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000107
GO:0050852	T cell receptor signaling pathway	Biological Process	IDA	PMID:8943371
GO:0007131	reciprocal meiotic recombination	Biological Process	ISS	GO_REF:0000024
GO:0007140	male meiotic nuclear division	Biological Process	ISS	GO_REF:0000024
GO:0010526	transposable element silencing	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0030163	protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0031507	heterochromatin formation	Biological Process	ISS	GO_REF:0000024
GO:0032007	negative regulation of TOR signaling	Biological Process	IEA	GO_REF:0000117
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:15548684
GO:0050862	positive regulation of T cell receptor signaling pathway	Biological Process	IDA	PMID:38225265
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:38225265
GO:0071233	cellular response to L-leucine	Biological Process	IEA	GO_REF:0000117
GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0000785	chromatin	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-983140
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:22190034
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0070728	L-leucine binding	Molecular Function	IEA	GO_REF:0000117
GO:0141053	histone H2A ubiquitin ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

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