TRI59

Details:

UniProt Entry: Q8IWR1
Gene: TRIM59
Class: RING
Family: RING5
Protein length: 403
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q8IWR1
MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENILQA SGNFYIWRPL RIPLKCPNCR
SITEIAPTGI ESLPVNFALR AIIEKYQQED HPDIVTCPEH YRQPLNVYCL LDKKLVCGHC
LTIGQHHGHP IDDLQSAYLK EKDTPQKLLE QLTDTHWTDL THLIEKLKEQ KSHSEKMIQG
DKEAVLQYFK ELNDTLEQKK KSFLTALCDV GNLINQEYTP QIERMKEIRE QQLELMALTI
SLQEESPLKF LEKVDDVRQH VQILKQRPLP EVQPVEIYPR VSKILKEEWS RTEIGQIKNV
LIPKMKISPK RMSCSWPGKD EKEVEFLKIL NIVVVTLISV ILMSILFFNQ HIITFLSEIT
LIWFSEASLS VYQSLSNSLH KVKNILCHIF YLLKEFVWKI VSH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	93	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
10	60	Domain	Zinc finger, RING-type	IPR001841	PS50089
10	43	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
10	59	Domain	Zinc finger, RING-type	IPR001841	SM00184
25	34	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
92	134	Domain	B-box-type zinc finger	IPR000315	PS50119
96	132	Domain	B-box-type zinc finger	IPR000315	PF00643

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000117
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0046597	host-mediated suppression of symbiont invasion	Biological Process	IEA	GO_REF:0000107
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030992	intraciliary transport particle B	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


P35813	PPM1A	Yes	No	No	No	—	No	Cluster-specific

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