SIAH1

>Q8IUQ4
MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL
VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY ASSGCEITLP HTEKADHEEL
CEFRPYSCPC PGASCKWQGS LDAVMPHLMH QHKSITTLQG EDIVFLATDI NLPGAVDWVM
MQSCFGFHFM LVLEKQEKYD GHQQFFAIVQ LIGTRKQAEN FAYRLELNGH RRRLTWEATP
RSIHEGIATA IMNSDCLVFD TSIAQLFAEN GNLGINVTIS MC

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
13	281	Family	E3 ubiquitin-protein ligase SINA-like, animal	IPR004162	PTHR45877
25	91	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
41	76	Domain	Zinc finger, RING-type	IPR001841	PS50089
82	278	Domain	Seven-in-absentia protein, TRAF-like domain	IPR018121	PF03145
92	148	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
93	153	Domain	Zinc finger, SIAH-type	IPR013010	PS51081
149	282	Homologous_superfamily	TRAF-like	IPR008974	G3DSA:2.60.210.10

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0060070	canonical Wnt signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:1990000	amyloid fibril formation	Biological Process	IEA	GO_REF:0000117
GO:2001233	regulation of apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000043
GO:0007399	nervous system development	Biological Process	TAS	PMID:9334332
GO:0007411	axon guidance	Biological Process	TAS	PMID:9334332
GO:0009653	anatomical structure morphogenesis	Biological Process	TAS	PMID:9403064
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0030163	protein catabolic process	Biological Process	IDA	PMID:11389840
GO:0031648	protein destabilization	Biological Process	IEA	GO_REF:0000107
GO:0043065	positive regulation of apoptotic process	Biological Process	IDA	PMID:21185211
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0051402	neuron apoptotic process	Biological Process	ISS	GO_REF:0000024
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Biological Process	IMP	PMID:21185211
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005769	early endosome	Cellular Component	IEA	GO_REF:0000107
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000107
GO:0030877	beta-catenin destruction complex	Cellular Component	IDA	PMID:16085652
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:11389840
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:21988832

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P41594	GRM5	Yes	Yes	No	No	—	No	E3-specific
P60903	S10AA	Yes	No	No	No	—	No	E3-specific
P40305	IFI27	Yes	No	No	No	—	No	E3-specific
Q96RU7	TRIB3	Yes	Yes	No	Yes	—	No	E3-specific
Q96KS0	EGLN2	Yes	Yes	No	No	—	No	Cluster-specific
P55199	ELL	Yes	No	No	No	—	No	E3-specific
Q9P212	PLCE1	Yes	Yes	No	No	—	No	Cluster-specific
P36888	FLT3	Yes	Yes	No	No	—	No	Cluster-specific
Q15554	TERF2	Yes	Yes	No	No	—	No	E3-specific
O00472	ELL2	Yes	Yes	No	No	—	No	E3-specific
Q9HB71	CYBP	Yes	Yes	Yes	No	11389839, 25241761	EBI-7857346	Cluster-specific
P43146	DCC	Yes	Yes	No	No	31413325	EBI-21386344	Cluster-specific
P49675	STAR	Yes	Yes	No	No	—	No	E3-specific
Q16633	OBF1	Yes	Yes	Yes	No	11483518	EBI-8830555	Cluster-specific
Q9GZT9	EGLN1	Yes	Yes	No	No	—	No	Cluster-specific
Q9UPY8	MARE3	Yes	Yes	Yes	No	32296183	EBI-24480706	E3-specific
Q6IE81	JADE1	Yes	Yes	No	No	—	No	E3-specific
O75525	KHDR3	Yes	Yes	No	No	16189514	EBI-760273	E3-specific
Q9NWT6	HIF1N	Yes	Yes	No	No	—	No	E3-specific
P51825	AFF1	Yes	Yes	No	No	—	No	E3-specific
Q9H6Z9	EGLN3	Yes	Yes	No	No	—	No	Cluster-specific
P98161	PKD1	Yes	Yes	No	No	—	No	E3-specific
P10242	MYB	Yes	Yes	No	No	—	No	E3-specific