RN135

Details:

UniProt Entry: Q8IUD6
Gene: RNF135
Class: RING
Family: RING5
Protein length: 432
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 7jl1, 7jl3

Protein Sequence ▾

>Q8IUD6
MAGLGLGSAV PVWLAEDDLG CIICQGLLDW PATLPCGHSF CRHCLEALWG ARDARRWACP
TCRQGAAQQP HLRKNTLLQD LADKYRRAAR EIQAGSDPAH CPCPGSSSLS SAAARPRRRP
ELQRVAVEKS ITEVAQELTE LVEHLVDIVR SLQNQRPLSE SGPDNELSIL GKAFSSGVDL
SMASPKLVTS DTAAGKIRDI LHDLEEIQEK LQESVTWKEA PEAQMQGELL EAPSSSSCPL
PDQSHPALRR ASRFAQWAIH PTFNLKSLSC SLEVSKDSRT VTVSHRPQPY RWSCERFSTS
QVLCSQALSS GKHYWEVDTR NCSHWAVGVA SWEMSRDQVL GRTMDSCCVE WKGTSQLSAW
HMVKETVLGS DRPGVVGIWL NLEEGKLAFY SVDNQEKLLY ECTISASSPL YPAFWLYGLH
PGNYLIIKQV KV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
13	91	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
21	62	Domain	Zinc finger, RING-type	IPR001841	SM00184
21	63	Domain	Zinc finger, RING-type	IPR001841	PS50089
36	45	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
241	432	Domain	B30.2/SPRY domain	IPR001870	PS50188
243	421	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
253	420	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
258	309	Domain	SPRY-associated	IPR006574	SM00589
261	428	Domain	RNF135, PRY/SPRY domain	IPR042723	cd12902
274	291	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
310	431	Domain	SPRY domain	IPR003877	SM00449
312	417	Domain	SPRY domain	IPR003877	PF00622
325	338	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
367	391	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
398	416	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0010994	free ubiquitin chain polymerization	Biological Process	IDA	PMID:31006531
GO:0032728	positive regulation of interferon-beta production	Biological Process	IMP	PMID:19017631
GO:0039529	RIG-I signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0045088	regulation of innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0051260	protein homooligomerization	Biological Process	IDA	PMID:31006531
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:31006531
GO:0140374	antiviral innate immune response	Biological Process	IEA	GO_REF:0000117
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-168909
GO:0010494	cytoplasmic stress granule	Cellular Component	IEA	GO_REF:0000044
GO:1990904	ribonucleoprotein complex	Cellular Component	IDA	PMID:31006531
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:19017631
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0039552	RIG-I binding	Molecular Function	IPI	PMID:23950712
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:25416956
GO:0043021	ribonucleoprotein complex binding	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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