MIB1

Details:

UniProt Entry: Q86YT6
Gene: MIB1
Class: RING
Family: RING7
Protein length: 1006
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 4tse, 4xi6, 4xi7, 4xib

Protein Sequence ▾

>Q86YT6
MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV VWDNGTAANY
RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC AECTNYDLCT VCYHGDKHHL
RHRFYRITTP GSERVLLESR RKSKKITARG IFAGARVVRG VDWQWEDQDG GNGRRGKVTE
IQDWSASSPH SAAYVLWDNG AKNLYRVGFE GMSDLKCVQD AKGGSFYRDH CPVLGEQNGN
RNPGGLQIGD LVNIDLDLEI VQSLQHGHGG WTDGMFETLT TTGTVCGIDE DHDIVVQYPS
GNRWTFNPAV LTKANIVRSG DAAQGAEGGT SQFQVGDLVQ VCYDLERIKL LQRGHGEWAE
AMLPTLGKVG RVQQIYSDSD LKVEVCGTSW TYNPAAVSKV ASAGSAISNA SGERLSQLLK
KLFETQESGD LNEELVKAAA NGDVAKVEDL LKRPDVDVNG QCAGHTAMQA ASQNGHVDIL
KLLLKQNVDV EAEDKDGDRA VHHAAFGDEG AVIEVLHRGS ADLNARNKRR QTPLHIAVNK
GHLQVVKTLL DFGCHPSLQD SEGDTPLHDA ISKKRDDILA VLLEAGADVT ITNNNGFNAL
HHAALRGNPS AMRVLLSKLP RPWIVDEKKD DGYTALHLAA LNNHVEVAEL LVHQGNANLD
IQNVNQQTAL HLAVERQHTQ IVRLLVRAGA KLDIQDKDGD TPLHEALRHH TLSQLRQLQD
MQDVGKVDAA WEPSKNTLIM GLGTQGAEKK SAASIACFLA ANGADLSIRN KKGQSPLDLC
PDPNLCKALA KCHKEKVSGQ VGSRSPSMIS NDSETLEECM VCSDMKRDTL FGPCGHIATC
SLCSPRVKKC LICKEQVQSR TKIEECVVCS DKKAAVLFQP CGHMCACENC ANLMKKCVQC
RAVVERRVPF IMCCGGKSSE DATDDISSGN IPVLQKDKDN TNVNADVQKL QQQLQDIKEQ
TMCPVCLDRL KNMIFLCGHG TCQLCGDRMS ECPICRKAIE RRILLY

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
6	74	Domain	Mib-herc2	IPR010606	PS51416
11	73	Homologous_superfamily	Mib/herc2 domain superfamily	IPR037252	SSF159034
15	71	Domain	Mib-herc2	IPR010606	PF06701
77	128	Homologous_superfamily	Zinc finger, ZZ-type superfamily	IPR043145	G3DSA:3.30.60.90
79	124	Domain	Zinc finger, ZZ-type	IPR000433	SM00291
79	122	Domain	Zinc finger, ZZ-type	IPR000433	PF00569
80	132	Domain	Zinc finger, ZZ-type	IPR000433	PS50135
83	127	Domain	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type	IPR042056	cd02339
85	112	Domain	Zinc finger, ZZ-type	IPR000433	PS01357
143	221	Domain	Mib-herc2	IPR010606	PS51416
145	220	Homologous_superfamily	Mib/herc2 domain superfamily	IPR037252	SSF159034
154	219	Domain	Mib-herc2	IPR010606	PF06701
246	311	Domain	Mind bomb, SH3 repeat domain	IPR040847	PF18346
333	397	Domain	Mind bomb, SH3 repeat domain	IPR040847	PF18346
421	533	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
430	460	Repeat	Ankyrin repeat	IPR002110	SM00248
434	781	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	SSF48403
463	495	Repeat	Ankyrin repeat	IPR002110	PS50088
463	492	Repeat	Ankyrin repeat	IPR002110	SM00248
496	525	Repeat	Ankyrin repeat	IPR002110	SM00248
496	528	Repeat	Ankyrin repeat	IPR002110	PS50088
511	593	Repeat	Ankyrin repeat	IPR002110	PF12796
529	558	Repeat	Ankyrin repeat	IPR002110	SM00248
529	561	Repeat	Ankyrin repeat	IPR002110	PS50088
534	625	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
562	594	Repeat	Ankyrin repeat	IPR002110	PS50088
562	591	Repeat	Ankyrin repeat	IPR002110	SM00248
595	626	Repeat	Ankyrin repeat	IPR002110	SM00248
595	662	Repeat	Ankyrin repeat	IPR002110	PF12796
626	669	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
631	655	Repeat	Ankyrin repeat	IPR002110	PS50088
631	661	Repeat	Ankyrin repeat	IPR002110	SM00248
632	647	Repeat	Ankyrin repeat	IPR002110	PR01415
665	694	Repeat	Ankyrin repeat	IPR002110	SM00248
665	697	Repeat	Ankyrin repeat	IPR002110	PS50088
668	715	Repeat	Ankyrin repeat	IPR002110	PF13637
670	801	Homologous_superfamily	Ankyrin repeat-containing domain superfamily	IPR036770	G3DSA:1.25.40.20
681	695	Repeat	Ankyrin repeat	IPR002110	PR01415
698	729	Repeat	Ankyrin repeat	IPR002110	SM00248
807	858	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
819	853	Domain	Zinc finger, RING-type	IPR001841	SM00184
819	854	Domain	Zinc finger, RING-type	IPR001841	PS50089
859	911	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
866	900	Domain	Zinc finger, RING-type	IPR001841	SM00184
866	901	Domain	Zinc finger, RING-type	IPR001841	PS50089
938	1006	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
963	996	Domain	Zinc finger, RING-type	IPR001841	PS50089
963	995	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0021953	central nervous system neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0001568	blood vessel development	Biological Process	IEA	GO_REF:0000107
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0001756	somitogenesis	Biological Process	IEA	GO_REF:0000107
GO:0001841	neural tube formation	Biological Process	IEA	GO_REF:0000107
GO:0001947	heart looping	Biological Process	IEA	GO_REF:0000107
GO:0007507	heart development	Biological Process	IEA	GO_REF:0000107
GO:0045665	negative regulation of neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045807	positive regulation of endocytosis	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:23615451
GO:0006897	endocytosis	Biological Process	IBA	GO_REF:0000033
GO:0007219	Notch signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0014069	postsynaptic density	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0005813	centrosome	Cellular Component	IDA	PMID:21399614
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-2737728
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000107
GO:0034451	centriolar satellite	Cellular Component	IEA	GO_REF:0000044
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:21903422
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9HCM4	E41L5	Yes	No	No	No	—	No	E3-specific
Q16637	SMN	Yes	Yes	No	No	—	No	E3-specific
P78504	JAG1	Yes	Yes	No	No	—	No	E3-specific
O15078	CE290	Yes	Yes	No	No	26638075	EBI-11362224	E3-specific
Q86YT6	MIB1	Yes	Yes	No	No	—	No	E3-specific
Q9UPN4	CP131	Yes	Yes	No	No	—	No	E3-specific
Q15154	PCM1	Yes	Yes	No	No	26638075	EBI-11362583	E3-specific

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