CACL1

Details:

UniProt Entry: Q86Y37
Gene: CACUL1
Class: Other E3 Components
Family: Scaffold
Protein length: 369
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q86Y37
MEESMEEEEG GSYEAMMDDQ NHNNWEAAVD GFRQPLPPPP PPSSIPAPAR EPPGGQLLAV
PAVSVDRKGP KEGLPMGPQP PPEANGVIMM LKSCDAAAAV AKAAPAPTAS STININTSTS
KFLMNVITIE DYKSTYWPKL DGAIDQLLTQ SPGDYIPISY EQIYSCVYKC VCQQHSEQMY
SDLIKKITNH LERVSKELQA SPPDLYIERF NIALGQYMGA LQSIVPLFIY MNKFYIETKL
NRDLKDDLIK LFTEHVAEKH IYSLMPLLLE AQSTPFQVTP STMANIVKGL YTLRPEWVQM
APTLFSKFIP NILPPAVESE LSEYAAQDQK FQRELIQNGF TRGDQSRKRA GDELAYNSSS
ACASSRGYR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	368	Family	CDK2-associated and cullin domain-containing protein 1	IPR042652	PTHR46636
131	334	Homologous_superfamily	Cullin repeat-like-containing domain superfamily	IPR016159	SSF74788
137	293	Domain	Cullin, N-terminal	IPR001373	PF00888

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IBA	GO_REF:0000033
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0008284	positive regulation of cell population proliferation	Biological Process	IMP	PMID:19829063
GO:0045860	positive regulation of protein kinase activity	Biological Process	IMP	PMID:19829063
GO:0005515	protein binding	Molecular Function	IPI	PMID:23178685
GO:0019901	protein kinase binding	Molecular Function	IBA	GO_REF:0000033
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA	GO_REF:0000002

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