DTX1

Details:

UniProt Entry: Q86Y01
Gene: DTX1
Class: RING
Family: RING9
Protein length: 620
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 6y5n, 6y5p

Protein Sequence ▾

>Q86Y01
MSRPGHGGLM PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV
VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA
YDMDICITIQ NAYEKQHPWL DLSSLGFCYL IYFNSMSQMN RQTRRRRRLR RRLDLAYPLT
VGSIPKSQSW PVGASSGQPC SCQQCLLVNS TRAASNAILA SQRRKAPPAP PLPPPPPPGG
PPGALAVRPS ATFTGAALWA APAAGPAEPA PPPGAPPRSP GAPGGARTPG QNNLNRPGPQ
RTTSVSARAS IPPGVPALPV KNLNGTGPVH PALAGMTGIL LCAAGLPVCL TRAPKPILHP
PPVSKSDVKP VPGVPGVCRK TKKKHLKKSK NPEDVVRRYM QKVKNPPDED CTICMERLVT
ASGYEGVLRH KGVRPELVGR LGRCGHMYHL LCLVAMYSNG NKDGSLQCPT CKAIYGEKTG
TQPPGKMEFH LIPHSLPGFP DTQTIRIVYD IPTGIQGPEH PNPGKKFTAR GFPRHCYLPN
NEKGRKVLRL LITAWERRLI FTIGTSNTTG ESDTVVWNEI HHKTEFGSNL TGHGYPDASY
LDNVLAELTA QGVSEAAAKA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	615	Family	Deltex family	IPR039398	PTHR12622
14	94	Domain	WWE domain	IPR004170	PS50918
17	96	Homologous_superfamily	WWE domain superfamily	IPR037197	G3DSA:3.30.720.50
23	106	Homologous_superfamily	WWE domain superfamily	IPR037197	SSF117839
23	102	Domain	WWE domain, subgroup	IPR018123	SM00678
26	94	Domain	WWE domain	IPR004170	PF02825
95	171	Domain	WWE domain	IPR004170	PS50918
95	185	Homologous_superfamily	WWE domain superfamily	IPR037197	SSF117839
97	181	Homologous_superfamily	WWE domain superfamily	IPR037197	G3DSA:3.30.720.50
104	179	Domain	WWE domain, subgroup	IPR018123	SM00678
108	171	Domain	WWE domain	IPR004170	PF02825
391	475	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
411	471	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
411	472	Domain	Zinc finger, RING-type	IPR001841	PS50089
411	471	Domain	Zinc finger, RING-type	IPR001841	SM00184
478	614	Homologous_superfamily	Deltex, C-terminal domain superfamily	IPR039399	G3DSA:3.30.390.130
479	613	Domain	Deltex, C-terminal	IPR039396	PF18102
480	612	Domain	Deltex, C-terminal	IPR039396	cd09633

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0030217	T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0010001	glial cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045581	negative regulation of T cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:1990830	cellular response to leukemia inhibitory factor	Biological Process	IEA	GO_REF:0000107
GO:0006351	DNA-templated transcription	Biological Process	NAS	PMID:11564735
GO:0006366	transcription by RNA polymerase II	Biological Process	TAS	PMID:9590294
GO:0007166	cell surface receptor signaling pathway	Biological Process	TAS	PMID:9590294
GO:0007219	Notch signaling pathway	Biological Process	IBA	GO_REF:0000033
GO:0008593	regulation of Notch signaling pathway	Biological Process	IGI	PMID:11564735
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0045665	negative regulation of neuron differentiation	Biological Process	IGI	PMID:11564735
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0003713	transcription coactivator activity	Molecular Function	TAS	PMID:9590294
GO:0005112	Notch binding	Molecular Function	IDA	PMID:11564735
GO:0005515	protein binding	Molecular Function	IPI	PMID:17028573
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0017124	SH3 domain binding	Molecular Function	IEA	GO_REF:0000043
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:17028573
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q13233	M3K1	Yes	Yes	No	No	—	No	E3-specific

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