TRI50

Details:

UniProt Entry: Q86XT4
Gene: TRIM50
Class: RING
Family: RING5
Protein length: 487
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q86XT4
MAWQVSLPEL EDRLQCPICL EVFKEPLMLQ CGHSYCKGCL VSLSCHLDAE LRCPVCRQAV
DGSSSLPNVS LARVIEALRL PGDPEPKVCV HHRNPLSLFC EKDQELICGL CGLLGSHQHH
PVTPVSTVYS RMKEELAALI SELKQEQKKV DELIAKLVNN RTRIVNESDV FSWVIRREFQ
ELHHLVDEEK ARCLEGIGGH TRGLVASLDM QLEQAQGTRE RLAQAECVLE QFGNEDHHKF
IRKFHSMASR AEMPQARPLE GAFSPISFKP GLHQADIKLT VWKRLFRKVL PAPEPLKLDP
ATAHPLLELS KGNTVVQCGL LAQRRASQPE RFDYSTCVLA SRGFSCGRHY WEVVVGSKSD
WRLGVIKGTA SRKGKLNRSP EHGVWLIGLK EGRVYEAFAC PRVPLPVAGH PHRIGLYLHY
EQGELTFFDA DRPDDLRPLY TFQADFQGKL YPILDTCWHE RGSNSLPMVL PPPSGPGPLS
PEQPTKL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	80	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	54	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
16	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
84	125	Domain	B-box-type zinc finger	IPR000315	PS50119
84	125	Domain	B-box-type zinc finger	IPR000315	SM00336
85	125	Domain	B-box-type zinc finger	IPR000315	PF00643
276	475	Domain	B30.2/SPRY domain	IPR001870	PS50188
284	470	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
287	472	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
292	309	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
293	345	Domain	SPRY-associated	IPR006574	SM00589
296	344	Domain	SPRY-associated	IPR006574	PF13765
331	355	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
346	474	Domain	SPRY domain	IPR003877	SM00449
348	453	Domain	SPRY domain	IPR003877	PF00622
361	374	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
405	429	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:22829933

Enzyme–Substrate Interactions ▾


Q86XT4	TRI50	Yes	No	Yes	Yes	22829933, 32296183	EBI-9867424	E3-specific

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