GOLI

Details:

UniProt Entry: Q86XS8
Gene: RNF130
Class: RING
Family: RING3
Protein length: 419
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q86XS8
MSCAGRAGPA RLAALALLTC SLWPARADNA SQEYYTALIN VTVQEPGRGA PLTFRIDRGR
YGLDSPKAEV RGQVLAPLPL HGVADHLGCD PQTRFFVPPN IKQWIALLQR GNCTFKEKIS
RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG DIIAVMITEL RGKDILSYLE KNISVQMTIA
VGTRMPPKNF SRGSLVFVSI SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK
AISKLTTRTV KKGDKETDPD FDHCAVCIES YKQNDVVRIL PCKHVFHKSC VDPWLSEHCT
CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR SALGDLAGDN SLGLEPLRTS
GISPLPQDGE LTPRTGEINI AVTKEWFIIA SFGLLSALTL CYMIIRATAS LNANEVEWF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
75	164	Domain	PA domain	IPR003137	PF02225
98	172	Homologous_superfamily	PA domain superfamily	IPR046450	SSF52025
222	310	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
263	305	Domain	Zinc finger, RING-type	IPR001841	PF13639
264	304	Domain	Zinc finger, RING-type	IPR001841	SM00184
264	305	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0012501	programmed cell death	Biological Process	ISS	PMID:13679316
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:16549277
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q15836	VAMP3	Yes	Yes	No	No	—	No	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.