FBX11

Details:

UniProt Entry: Q86XK2
Gene: FBXO11
Class: RING
Family: RING1
Protein length: 927
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 5vmd

Protein Sequence ▾

>Q86XK2
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PQQQPPPPPQ QQQQQQPPPP
PPPPPPLPQE RNNVGERDDD VPADMVAEES GPGAQNSPYQ LRRKTLLPKR TACPTKNSME
GASTSTTENF GHRAKRARVS GKSQDLSAAP AEQYLQEKLP DEVVLKIFSY LLEQDLCRAA
CVCKRFSELA NDPILWKRLY MEVFEYTRPM MHPEPGKFYQ INPEEYEHPN PWKESFQQLY
KGAHVKPGFA EHFYSNPARY KGRENMLYYD TIEDALGGVQ EAHFDGLIFV HSGIYTDEWI
YIESPITMIG AAPGKVADKV IIENTRDSTF VFMEGSEDAY VGYMTIRFNP DDKSAQHHNA
HHCLEITVNC SPIIDHCIIR STCTVGSAVC VSGQGACPTI KHCNISDCEN VGLYITDHAQ
GIYEDNEISN NALAGIWVKN HGNPIIRRNH IHHGRDVGVF TFDHGMGYFE SCNIHRNRIA
GFEVKAYANP TVVRCEIHHG QTGGIYVHEK GRGQFIENKI YANNFAGVWI TSNSDPTIRG
NSIFNGNQGG VYIFGDGRGL IEGNDIYGNA LAGIQIRTNS CPIVRHNKIH DGQHGGIYVH
EKGQGVIEEN EVYSNTLAGV WVTTGSTPVL RRNRIHSGKQ VGVYFYDNGH GVLEDNDIYN
HMYSGVQIRT GSNPKIRRNK IWGGQNGGIL VYNSGLGCIE DNEIFDNAMA GVWIKTDSNP
TLRRNKIHDG RDGGICIFNG GRGLLEENDI FRNAQAGVLI STNSHPILRK NRIFDGFAAG
IEITNHATAT LEGNQIFNNR FGGLFLASGV NVTMKDNKIM NNQDAIEKAV SRGQCLYKIS
SYTSYPMHDF YRCHTCNTTD RNAICVNCIK KCHQGHDVEF IRHDRFFCDC GAGTLSNPCT
LAGEPTHDTD TLYDSAPPIE SNTLQHN

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
153	199	Domain	F-box domain	IPR001810	PS50181
158	201	Domain	F-box domain	IPR001810	PF12937
158	241	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
159	199	Domain	F-box domain	IPR001810	SM00256
269	492	Homologous_superfamily	Pectin lyase fold/virulence factor	IPR011050	SSF51126
270	527	Homologous_superfamily	Pectin lyase fold	IPR012334	G3DSA:2.160.20.10
374	479	Domain	Periplasmic copper-binding protein NosD, beta helix domain	IPR007742	PF05048
395	417	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
412	450	Repeat	Parallel beta-helix repeat-2	IPR022441	TIGR03804
418	440	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
418	554	Domain	Carbohydrate-binding/sugar hydrolysis domain	IPR006633	SM00722
441	463	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
464	486	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
481	627	Domain	Right handed beta helix domain	IPR039448	PF13229
487	509	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
504	546	Repeat	Parallel beta-helix repeat-2	IPR022441	TIGR03804
510	532	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
523	711	Homologous_superfamily	Pectin lyase fold/virulence factor	IPR011050	SSF51126
533	555	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
556	578	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
570	692	Domain	Carbohydrate-binding/sugar hydrolysis domain	IPR006633	SM00722
579	601	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
582	719	Homologous_superfamily	Pectin lyase fold	IPR012334	G3DSA:2.160.20.10
596	637	Repeat	Parallel beta-helix repeat-2	IPR022441	TIGR03804
602	624	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
625	647	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
648	670	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
664	819	Domain	Right handed beta helix domain	IPR039448	PF13229
664	826	Homologous_superfamily	Pectin lyase fold/virulence factor	IPR011050	SSF51126
671	693	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
688	729	Repeat	Parallel beta-helix repeat-2	IPR022441	TIGR03804
694	716	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
708	837	Domain	Carbohydrate-binding/sugar hydrolysis domain	IPR006633	SM00722
717	739	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
720	879	Homologous_superfamily	Pectin lyase fold	IPR012334	G3DSA:2.160.20.10
740	762	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
763	785	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
786	808	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
809	830	Repeat	Parallel beta-helix repeat	IPR006626	SM00710
833	904	Domain	Zinc finger, UBR-type	IPR003126	PS51157
838	903	Domain	Zinc finger, UBR-type	IPR003126	SM00396
848	894	Domain	Zinc finger, UBR-type	IPR003126	PF02207

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0001837	epithelial to mesenchymal transition	Biological Process	IDA	PMID:16096638
GO:0007605	sensory perception of sound	Biological Process	IEA	GO_REF:0000107
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0010719	negative regulation of epithelial to mesenchymal transition	Biological Process	IDA	PMID:25827072
GO:0042981	regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:16487488
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS	PMID:10531035
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:17098746
GO:0016274	protein-arginine N-methyltransferase activity	Molecular Function	IDA	PMID:16487488
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:25827072

Enzyme–Substrate Interactions ▾


P41182	BCL6	Yes	Yes	Yes	Yes	22113614	EBI-15955236	E3-specific
O75626	PRDM1	Yes	Yes	No	No	—	No	E3-specific
Q9NZJ0	DTL	Yes	Yes	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P41182	BCL6	Yes	Yes	Yes	Yes	22113614	EBI-15955236	E3-specific
O75626	PRDM1	Yes	Yes	No	No	—	No	E3-specific
Q9NZJ0	DTL	Yes	Yes	No	No	—	No	E3-specific