TRI69

Details:

UniProt Entry: Q86WT6
Gene: TRIM69
Class: RING
Family: RING5
Protein length: 500
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 4nqj, 6yxe

Protein Sequence ▾

>Q86WT6
MEVSTNPSSN IDPGDYVEMN DSITHLPSKV VIQDITMELH CPLCNDWFRD PLMLSCGHNF
CEACIQDFWR LQAKETFCPE CKMLCQYNNC TFNPVLDKLV EKIKKLPLLK GHPQCPEHGE
NLKLFSKPDG KLICFQCKDA RLSVGQSKEF LQISDAVHFF TEELAIQQGQ LETTLKELQT
LRNMQKEAIA AHKENKLHLQ QHVSMEFLKL HQFLHSKEKD ILTELREEGK ALNEEMELNL
SQLQEQCLLA KDMLVSIQAK TEQQNSFDFL KDITTLLHSL EQGMKVLATR ELISRKLNLG
QYKGPIQYMV WREMQDTLCP GLSPLTLDPK TAHPNLVLSK SQTSVWHGDI KKIMPDDPER
FDSSVAVLGS RGFTSGKWYW EVEVAKKTKW TVGVVRESII RKGSCPLTPE QGFWLLRLRN
QTDLKALDLP SFSLTLTNNL DKVGIYLDYE GGQLSFYNAK TMTHIYTFSN TFMEKLYPYF
CPCLNDGGEN KEPLHILHPQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
24	112	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
41	82	Domain	Zinc finger, RING-type	IPR001841	PS50089
41	81	Domain	Zinc finger, RING-type	IPR001841	SM00184
56	65	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
305	500	Domain	B30.2/SPRY domain	IPR001870	PS50188
317	498	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
321	338	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
322	374	Domain	SPRY-associated	IPR006574	SM00589
323	500	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
325	373	Domain	SPRY-associated	IPR006574	PF13765
338	355	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
360	384	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
375	500	Domain	SPRY domain	IPR003877	SM00449
377	481	Domain	SPRY domain	IPR003877	PF00622
390	403	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
434	458	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
464	482	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0007098	centrosome cycle	Biological Process	IMP	PMID:18477460
GO:0051299	centrosome separation	Biological Process	IDA	PMID:18086858
GO:0071539	protein localization to centrosome	Biological Process	IDA	PMID:21076410
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-983140
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000117
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:23131556
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514

Enzyme–Substrate Interactions ▾

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