ZBT46

Details:

UniProt Entry: Q86UZ6
Gene: ZBTB46
Class: RING
Family: RING6
Protein length: 589
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q86UZ6
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY
CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA
CHDFIKAALD ISIKSDASDE LAEFEIGASS SSSTEALISA VMAGRSISPW LARRTSPANS
SGDSAIASCH DGGSSYGKED QEPKADGPDD VSSQPLWPGD VGYGPLRIKE EQVSPSQYGG
SELPSAKDGA VQNSFSEQSA GDAWQPTGRR KNRKNKETVR HITQQVEDDS RASSPVPSFL
PTSGWPFSSR DSNADLSVTE ASSSDSRGER AELYAQVEEG LLGGEASYLG PPLTPEKDDA
LHQATAVANL RAALMSKNSL LSLKADVLGD DGSLLFEYLP RGAHSLSLNE FTVIRKKFKC
PYCSFSAMHQ CILKRHMRSH TGERPYPCEI CGKKFTRREH MKRHTLVHSK DKKYVCKVCS
RVFMSAASVG IRHGSRRHGV CTDCAGRGMA GPLDHGGGGG EGSPEALFPG DGPYLEDPED
PRGEAEELGE DDEGLAPEDA LLADDKDEED SPRPRSPPGG PDKDFAWLS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	152	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
8	126	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
21	127	Domain	BTB/POZ domain	IPR000210	PF00651
31	99	Domain	BTB/POZ domain	IPR000210	PS50097
31	129	Domain	BTB/POZ domain	IPR000210	SM00225
418	445	Domain	Zinc finger C2H2-type	IPR013087	PS50157
418	440	Domain	Zinc finger C2H2-type	IPR013087	SM00355
430	483	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
446	473	Domain	Zinc finger C2H2-type	IPR013087	PS50157
446	468	Domain	Zinc finger C2H2-type	IPR013087	SM00355
448	468	Domain	Zinc finger C2H2-type	IPR013087	PS00028
474	498	Domain	Zinc finger C2H2-type	IPR013087	SM00355

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002273	plasmacytoid dendritic cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0030225	macrophage differentiation	Biological Process	IEA	GO_REF:0000107
GO:0030851	granulocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:0097028	dendritic cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0002695	negative regulation of leukocyte activation	Biological Process	IEA	GO_REF:0000107
GO:0030853	negative regulation of granulocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045650	negative regulation of macrophage differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045656	negative regulation of monocyte differentiation	Biological Process	IEA	GO_REF:0000107
GO:2001199	negative regulation of dendritic cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:2001200	positive regulation of dendritic cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	ISS	GO_REF:0000024
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000785	chromatin	Cellular Component	ISS	GO_REF:0000024
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000976	transcription cis-regulatory region binding	Molecular Function	ISS	GO_REF:0000024
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	ISA	GO_REF:0000113
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.