DTX2

Details:

UniProt Entry: Q86UW9
Gene: DTX2
Class: RING
Family: RING9
Protein length: 622
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 6ir0, 6y22, 6y2x, 6y3j

Protein Sequence ▾

>Q86UW9
MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK GQRFGLGSLA
HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF PQHSAPGRGV VWEWLSDDGS
WTAYEASVCD YLEQQVARGN QLVDLAPLGY NYTVNYTTHT QTNKTSSFCR SVRRQAGPPY
PVTTIIAPPG HTGVACSCHQ CLSGSRTGPV SGRYRHSMTN LPAYPVPQHP PHRTASVFGT
HQAFAPYNKP SLSGARSAPR LNTTNAWGAA PPSLGSQPLY RSSLSHLGPQ HLPPGSSTSG
AVSASLPSGP SSSPGSVPAT VPMQMPKPSR VQQALAGMTS VLMSAIGLPV CLSRAPQPTS
PPASRLASKS HGSVKRLRKM SVKGATPKPE PEPEQVIKNY TEELKVPPDE DCIICMEKLS
TASGYSDVTD SKAIGSLAVG HLTKCSHAFH LLCLLAMYCN GNKDGSLQCP SCKTIYGEKT
GTQPQGKMEV LRFQMSLPGH EDCGTILIVY SIPHGIQGPE HPNPGKPFTA RGFPRQCYLP
DNAQGRKVLE LLKVAWKRRL IFTVGTSSTT GETDTVVWNE IHHKTEMDRN ITGHGYPDPN
YLQNVLAELA AQGVTEDCLE QQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
8	97	Domain	WWE domain	IPR004170	PS50918
15	620	Family	Deltex family	IPR039398	PTHR12622
17	105	Domain	WWE domain, subgroup	IPR018123	SM00678
17	109	Homologous_superfamily	WWE domain superfamily	IPR037197	SSF117839
20	97	Domain	WWE domain	IPR004170	PF02825
22	97	Homologous_superfamily	WWE domain superfamily	IPR037197	G3DSA:3.30.720.50
98	174	Domain	WWE domain	IPR004170	PS50918
98	184	Homologous_superfamily	WWE domain superfamily	IPR037197	G3DSA:3.30.720.50
107	183	Homologous_superfamily	WWE domain superfamily	IPR037197	SSF117839
107	182	Domain	WWE domain, subgroup	IPR018123	SM00678
110	174	Domain	WWE domain	IPR004170	PF02825
392	476	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
412	473	Domain	Zinc finger, RING-type	IPR001841	PS50089
412	472	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
412	472	Domain	Zinc finger, RING-type	IPR001841	SM00184
479	615	Homologous_superfamily	Deltex, C-terminal domain superfamily	IPR039399	G3DSA:3.30.390.130
480	614	Domain	Deltex, C-terminal	IPR039396	PF18102
481	613	Domain	Deltex, C-terminal	IPR039396	cd09633

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0007219	Notch signaling pathway	Biological Process	IEA	GO_REF:0000002
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0031965	nuclear membrane	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000002
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514

Enzyme–Substrate Interactions ▾


Q86UW9	DTX2	Yes	No	No	No	25416956	EBI-10485722	E3-specific

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