ZN598

Details:

UniProt Entry: Q86UK7
Gene: ZNF598
Class: RING
Family: RING9
Protein length: 904
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q86UK7
MAAAGGAEGR RAALEAAAAA APERGGGSCV LCCGDLEATA LGRCDHPVCY RCSTKMRVLC
EQRYCAVCRE ELRQVVFGKK LPAFATIPIH QLQHEKKYDI YFADGKVYAL YRQLLQHECP
RCPELPPFSL FGDLEQHMRR QHELFCCRLC LQHLQIFTYE RKWYSRKDLA RHRMQGDPDD
TSHRGHPLCK FCDERYLDND ELLKHLRRDH YFCHFCDSDG AQDYYSDYAY LREHFREKHF
LCEEGRCSTE QFTHAFRTEI DLKAHRTACH SRSRAEARQN RHIDLQFSYA PRHSRRNEGV
VGGEDYEEVD RYSRQGRVAR AGTRGAQQSR RGSWRYKREE EDREVAAAVR ASVAAQQQEE
ARRSEDQEEG GRPKKEEAAA RGPEDPRGPR RSPRTQGEGP GPKETSTNGP VSQEAFSVTG
PAAPGCVGVP GALPPPSPKL KDEDFPSLSA STSSSCSTAA TPGPVGLALP YAIPARGRSA
FQEEDFPALV SSVPKPGTAP TSLVSAWNSS SSSKKVAQPP LSAQATGSGQ PTRKAGKGSR
GGRKGGPPFT QEEEEDGGPA LQELLSTRPT GSVSSTLGLA SIQPSKVGKK KKVGSEKPGT
TLPQPPPATC PPGALQAPEA PASRAEGPVA VVVNGHTEGP APARSAPKEP PGLPRPLGSF
PCPTPQEDFP ALGGPCPPRM PPPPGFSAVV LLKGTPPPPP PGLVPPISKP PPGFSGLLPS
PHPACVPSPA TTTTTKAPRL LPAPRAYLVP ENFRERNLQL IQSIRDFLQS DEARFSEFKS
HSGEFRQGLI SAAQYYKSCR DLLGENFQKV FNELLVLLPD TAKQQELLSA HTDFCNREKP
LSTKSKKNKK SAWQATTQQA GLDCRVCPTC QQVLAHGDAS SHQALHAARD DDFPSLQAIA
RIIT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
28	856	Family	E3 ubiquitin-protein ligase ZNF598/Hel2	IPR044288	PTHR22938
29	69	Domain	ZN598/Hel2, RING finger	IPR041888	cd16615
29	69	Domain	Zinc finger, RING-type	IPR001841	PS50089
117	142	Domain	Zinc finger C2H2-type	IPR013087	SM00355
187	210	Domain	Zinc finger C2H2-type	IPR013087	SM00355
189	210	Domain	Zinc finger C2H2-type	IPR013087	PS00028
211	239	Domain	Zinc finger C2H2-type	IPR013087	SM00355
240	270	Domain	Zinc finger C2H2-type	IPR013087	SM00355
865	886	Domain	Zinc finger C2H2-type	IPR013087	SM00355

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0072344	rescue of stalled ribosome	Biological Process	IEA	GO_REF:0000002
GO:0032790	ribosome disassembly	Biological Process	IDA	PMID:36302773
GO:0045947	negative regulation of translational initiation	Biological Process	IDA	PMID:32726578
GO:0006417	regulation of translation	Biological Process	IEA	GO_REF:0000043
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:28065601
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:36302773
GO:1990116	ribosome-associated ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:32099016
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0022626	cytosolic ribosome	Cellular Component	IDA	PMID:30293783
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22658674
GO:0005515	protein binding	Molecular Function	IPI	PMID:28065601
GO:0043022	ribosome binding	Molecular Function	IBA	GO_REF:0000033
GO:0055106	ubiquitin-protein transferase regulator activity	Molecular Function	IDA	PMID:30293783
GO:0140517	protein-RNA adaptor activity	Molecular Function	IDA	PMID:32726578
GO:0170011	stalled ribosome sensor activity	Molecular Function	IDA	PMID:30293783

Enzyme–Substrate Interactions ▾

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