SYVN1

Details:

UniProt Entry: Q86TM6
Gene: SYVN1
Class: RING
Family: RING9
Protein length: 617
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 6a3z

Protein Sequence ▾

>Q86TM6
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA FVLVFLLGKV
MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS PRFVALFTLL LFLKCFHWLA
EDRVDFMERS PNISWLFHCR IVSLMFLLGI LDFLFVSHAY HSILTRGASV QLVFGFEYAI
LMTMVLTIFI KYVLHSVDLQ SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF
PLFAIRPMYL AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT
GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD QGPPPAPHPP
PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS GEAVAPPSTS AAALSRPSGA
ATTTAAGTSA TAASATASGP GSGSAPEAGP APGFPFPPPW MGMPLPPPFA FPPMPVPPAG
FAGLTPEELR ALEGHERQHL EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV
NSTEETATTV VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA
AELRRRRLQK LESPVAH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
264	337	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
290	330	Domain	Zinc finger, RING-type	IPR001841	PF13639
291	329	Domain	Zinc finger, RING-type	IPR001841	SM00184
291	330	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0002826	negative regulation of T-helper 1 type immune response	Biological Process	IDA	PMID:16286920
GO:0036503	ERAD pathway	Biological Process	IMP	PMID:21245296
GO:0002327	immature B cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:14593114
GO:0030970	retrograde protein transport, ER to cytosol	Biological Process	IMP	PMID:25660456
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0050821	protein stabilization	Biological Process	IEA	GO_REF:0000117
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:14593114
GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Biological Process	IEA	GO_REF:0000117
GO:1904380	endoplasmic reticulum mannose trimming	Biological Process	TAS	Reactome:R-HSA-901032
GO:0012505	endomembrane system	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005783	endoplasmic reticulum	Cellular Component	IDA	PMID:37795761
GO:0044322	endoplasmic reticulum quality control compartment	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005790	smooth endoplasmic reticulum	Cellular Component	IDA	PMID:16186510
GO:0000836	Hrd1p ubiquitin ligase complex	Cellular Component	TAS	PMID:21454652
GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex	Cellular Component	IMP	PMID:26471130
GO:0036513	Derlin-1 retrotranslocation complex	Cellular Component	IDA	PMID:21454652
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0005515	protein binding	Molecular Function	IPI	PMID:17170702
GO:0051082	unfolded protein binding	Molecular Function	IPI	PMID:17059562
GO:0051087	protein-folding chaperone binding	Molecular Function	IPI	PMID:21636303
GO:0051117	ATPase binding	Molecular Function	IPI	PMID:16186510
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IEA	GO_REF:0000107
GO:1990381	ubiquitin-specific protease binding	Molecular Function	IPI	PMID:22590560

Enzyme–Substrate Interactions ▾

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q96AJ1	CLUA1	Yes	Yes	No	No	—	No	E3-specific
P01848	TRAC	Yes	No	No	No	—	No	E3-specific
Q86TM6	SYVN1	Yes	Yes	No	No	—	No	E3-specific
P22304	IDS	Yes	No	No	No	—	No	E3-specific
P78380	OLR1	Yes	No	No	No	—	No	E3-specific
Q96M98	PACRG	Yes	Yes	No	No	—	No	E3-specific
P05067	A4	Yes	Yes	No	No	—	No	E3-specific
Q8WZ42	TITIN	Yes	Yes	No	No	—	No	E3-specific
Q5T5C0	STXB5	Yes	No	No	No	—	No	E3-specific
Q92542	NICA	Yes	Yes	No	No	—	No	E3-specific
P01009	A1AT	Yes	Yes	No	No	—	No	Cluster-specific
P10909	CLUS	Yes	Yes	No	No	—	No	E3-specific
Q8WXF7	ATLA1	Yes	No	No	No	—	No	E3-specific

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