RN180

Details:

UniProt Entry: Q86T96
Gene: RNF180
Class: RING
Family: RING9
Protein length: 592
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q86T96
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW
HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT
DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE
ALCLEVRPTY FEMKNEKLLS KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT
LLPTLYEIHS KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH
ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE HLSPLDFLHS
ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY SGVGLLDHMT LNNEMSTDED
NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH IFCEPCLRTL AKDNPSSTPC PLCRTIISRV
FFQTELNNAT KTFFTKEYLK IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF
PHGAHRMDYL HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
12	592	Family	E3 ubiquitin-protein ligase RNF180	IPR033263	PTHR46717
370	500	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
432	473	Domain	Zinc finger, RING-type	IPR001841	SM00184
432	474	Domain	Zinc finger, RING-type	IPR001841	PS50089
448	457	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
491	591	Domain	E3 ubiquitin-protein ligase RNF180, C-terminal domain	IPR045790	PF19332

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0030534	adult behavior	Biological Process	IEA	GO_REF:0000107
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0042415	norepinephrine metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0042428	serotonin metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005635	nuclear envelope	Cellular Component	IEA	GO_REF:0000044
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:36931259
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾


P08134	RHOC	Yes	No	No	No	—	No	Cluster-specific
O95388	CCN4	Yes	No	No	No	—	No	E3-specific
O95409	ZIC2	Yes	Yes	No	No	—	No	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P08134	RHOC	Yes	No	No	No	—	No	Cluster-specific
O95388	CCN4	Yes	No	No	No	—	No	E3-specific
O95409	ZIC2	Yes	Yes	No	No	—	No	E3-specific