KAISO

Details:

UniProt Entry: Q86T24
Gene: ZBTB33
Class: RING
Family: RING6
Protein length: 672
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 2lt7, 3fkc, 3m4t, 3m8v, 4f6m, 4f6n, 5vmu, 5vmv, 5vmw, 5vmx, 5vmy, 5vmz, 6df5, 6df8, 6df9, 6dfa, 6dfb, 6dfc, 6v8u

Protein Sequence ▾

>Q86T24
MESRKLISAT DIQYSGSLLN SLNEQRGHGL FCDVTVIVED RKFRAHKNIL SASSTYFHQL
FSVAGQVVEL SFIRAEIFAE ILNYIYSSKI VRVRSDLLDE LIKSGQLLGV KFIAELGVPL
SQVKSISGTA QDGNTEPLPP DSGDKNLVIQ KSKDEAQDNG ATIMPIITES FSLSAEDYEM
KKIIVTDSDD DDDDVIFCSE ILPTKETLPS NNTVAQVQSN PGPVAISDVA PSASNNSPPL
TNITPTQKLP TPVNQATLSQ TQGSEKLLVS SAPTHLTPNI ILLNQTPLST PPNVSSSLPN
HMPSSINLLV QNQQTPNSAI LTGNKANEEE EEEIIDDDDD TISSSPDSAV SNTSLVPQAD
TSQNTSFDGS LIQKMQIPTL LQEPLSNSLK ISDIITRNTN DPGVGSKHLM EGQKIITLDT
ATEIEGLSTG CKVYANIGED TYDIVIPVKD DPDEGEARLE NEIPKTSGSE MANKRMKVKH
DDHYELIVDG RVYYICIVCK RSYVCLTSLR RHFNIHSWEK KYPCRYCEKV FPLAEYRTKH
EIHHTGERRY QCLACGKSFI NYQFMSSHIK SVHSQDPSGD SKLYRLHPCR SLQIRQYAYL
SDRSSTIPAM KDDGIGYKVD TGKEPPVGTT TSTQNKPMTW EDIFIQQEND SIFKQNVTDG
STEFEFIIPE SY

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	115	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
13	114	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
22	114	Domain	BTB/POZ domain	IPR000210	PF00651
32	94	Domain	BTB/POZ domain	IPR000210	PS50097
32	125	Domain	BTB/POZ domain	IPR000210	SM00225
491	522	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
494	516	Domain	Zinc finger C2H2-type	IPR013087	SM00355
494	521	Domain	Zinc finger C2H2-type	IPR013087	PS50157
496	516	Domain	Zinc finger C2H2-type	IPR013087	PS00028
516	568	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
522	544	Domain	Zinc finger C2H2-type	IPR013087	SM00355
522	549	Domain	Zinc finger C2H2-type	IPR013087	PS50157
524	544	Domain	Zinc finger C2H2-type	IPR013087	PS00028
550	573	Domain	Zinc finger C2H2-type	IPR013087	SM00355
550	578	Domain	Zinc finger C2H2-type	IPR013087	PS50157
552	573	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0035556	intracellular signal transduction	Biological Process	TAS	PMID:10207085
GO:0045892	negative regulation of DNA-templated transcription	Biological Process	IDA	PMID:16354688
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0000785	chromatin	Cellular Component	ISA	GO_REF:0000113
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	ISA	GO_REF:0000113
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:10207085
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0008327	methyl-CpG binding	Molecular Function	IEA	GO_REF:0000117
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA	PMID:20403812
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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