PCGF5

Details:

UniProt Entry: Q86SE9
Gene: PCGF5
Class: RING
Family: RING4
Protein length: 256
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 4s3o

Protein Sequence ▾

>Q86SE9
MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS NDCPRCGNQV
HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK NKPQENGQDD TSKADKPKVD
EEGDENEDDK DYHRSDPQIA ICLDCLRNNG QSGDNVVKGL MKKFIRCSTR VTVGTIKKFL
SLKLKLPSSY ELDVLCNGEI MGKDHTMEFI YMTRWRLRGE NFRCLNCSAS QVCSQDGPLY
QSYPMVLQYR PRIDFG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	101	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
18	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
18	56	Domain	Zinc finger, RING-type	IPR001841	PS50089
34	43	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
163	216	Domain	RAWUL domain	IPR032443	PF16207

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:25519132
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000117
GO:0060816	random inactivation of X chromosome	Biological Process	ISS	GO_REF:0000024
GO:0000805	X chromosome	Cellular Component	ISS	GO_REF:0000024
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005794	Golgi apparatus	Cellular Component	IDA	GO_REF:0000052
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000054
GO:0031519	PcG protein complex	Cellular Component	IEA	GO_REF:0000120
GO:0035102	PRC1 complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:19273555
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0140862	histone H2AK119 ubiquitin ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

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