SH3R1

Details:

UniProt Entry: Q7Z6J0
Gene: SH3RF1
Class: RING
Family: RING9
Protein length: 888
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 7nzc, 7nzd

Protein Sequence ▾

>Q7Z6J0
MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP ECRTLVGSGV
EELPSNILLV RLLDGIKQRP WKPGPGGGSG TNCTNALRSQ SSTVANCSSK DLQSSQGGQQ
PRVQSWSPPV RGIPQLPCAK ALYNYEGKEP GDLKFSKGDI IILRRQVDEN WYHGEVNGIH
GFFPTNFVQI IKPLPQPPPQ CKALYDFEVK DKEADKDCLP FAKDDVLTVI RRVDENWAEG
MLADKIGIFP ISYVEFNSAA KQLIEWDKPP VPGVDAGECS SAAAQSSTAP KHSDTKKNTK
KRHSFTSLTM ANKSSQASQN RHSMEISPPV LISSSNPTAA ARISELSGLS CSAPSQVHIS
TTGLIVTPPP SSPVTTGPSF TFPSDVPYQA ALGTLNPPLP PPPLLAATVL ASTPPGATAA
AAAAGMGPRP MAGSTDQIAH LRPQTRPSVY VAIYPYTPRK EDELELRKGE MFLVFERCQD
GWFKGTSMHT SKIGVFPGNY VAPVTRAVTN ASQAKVPMST AGQTSRGVTM VSPSTAGGPA
QKLQGNGVAG SPSVVPAAVV SAAHIQTSPQ AKVLLHMTGQ MTVNQARNAV RTVAAHNQER
PTAAVTPIQV QNAAGLSPAS VGLSHHSLAS PQPAPLMPGS ATHTAAISIS RASAPLACAA
AAPLTSPSIT SASLEAEPSG RIVTVLPGLP TSPDSASSAC GNSSATKPDK DSKKEKKGLL
KLLSGASTKR KPRVSPPASP TLEVELGSAE LPLQGAVGPE LPPGGGHGRA GSCPVDGDGP
VTTAVAGAAL AQDAFHRKAS SLDSAVPIAP PPRQACSSLG PVLNESRPVV CERHRVVVSY
PPQSEAELEL KEGDIVFVHK KREDGWFKGT LQRNGKTGLF PGSFVENI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	81	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
12	53	Domain	Zinc finger, RING-type	IPR001841	PS50089
12	52	Domain	Zinc finger, RING-type	IPR001841	SM00184
28	37	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
128	199	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
134	193	Domain	SH3 domain	IPR001452	PS50002
137	192	Domain	SH3 domain	IPR001452	SM00326
140	185	Domain	SH3 domain	IPR001452	PF00018
194	262	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
196	259	Domain	SH3 domain	IPR001452	PS50002
199	209	Domain	SH3 domain	IPR001452	PR00452
199	258	Domain	SH3 domain	IPR001452	SM00326
200	254	Domain	E3 ubiquitin-protein ligase SH3RF1, second SH3 domain	IPR035795	cd11930
203	255	Domain	SH3 domain	IPR001452	PF14604
442	520	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
445	506	Domain	SH3 domain	IPR001452	PS50002
448	505	Domain	SH3 domain	IPR001452	SM00326
452	502	Domain	SH3 domain	IPR001452	PF14604
462	477	Domain	SH3 domain	IPR001452	PR00452
492	504	Domain	SH3 domain	IPR001452	PR00452
801	887	Homologous_superfamily	SH3-like domain superfamily	IPR036028	SSF50044
829	888	Domain	SH3 domain	IPR001452	PS50002
832	888	Domain	SH3 domain	IPR001452	SM00326
833	887	Domain	SH3RF1/SH3RF3, fourth SH3 domain	IPR035816	cd11785
836	886	Domain	SH3 domain	IPR001452	PF14604

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000165	MAPK cascade	Biological Process	IEA	GO_REF:0000108
GO:0001764	neuron migration	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0043066	negative regulation of apoptotic process	Biological Process	IBA	GO_REF:0000033
GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:0046330	positive regulation of JNK cascade	Biological Process	ISS	GO_REF:0000024
GO:0051865	protein autoubiquitination	Biological Process	IEA	GO_REF:0000117
GO:1904044	response to aldosterone	Biological Process	IEA	GO_REF:0000107
GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	Biological Process	IMP	PMID:21586138
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0030027	lamellipodium	Cellular Component	ISS	GO_REF:0000024
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005078	MAP-kinase scaffold activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:20696164
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


P63252	KCNJ2	Yes	Yes	No	No	—	No	E3-specific
P48048	KCNJ1	Yes	Yes	No	No	—	No	E3-specific
Q7Z6J0	SH3R1	Yes	No	No	No	—	No	E3-specific
Q9UBP5	HEY2	Yes	Yes	No	No	—	No	E3-specific
Q15011	HERP1	Yes	Yes	No	No	—	No	Cluster-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P63252	KCNJ2	Yes	Yes	No	No	—	No	E3-specific
P48048	KCNJ1	Yes	Yes	No	No	—	No	E3-specific
Q7Z6J0	SH3R1	Yes	No	No	No	—	No	E3-specific
Q9UBP5	HEY2	Yes	Yes	No	No	—	No	E3-specific
Q15011	HERP1	Yes	Yes	No	No	—	No	Cluster-specific