RBBP6

Details:

UniProt Entry: Q7Z6E9
Gene: RBBP6
Class: RING
Family: RING10
Protein length: 1792
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 2c7h, 2ysa, 2yur, 3ztg, 6e5x

Protein Sequence ▾

>Q7Z6E9
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADCDLQITN AQTKEEYTDD
NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPAMATTK AIDDSSASIS LAQLTKTANL
AEANASEEDK IKAMMSQSGH EYDPINYMKK PLGPPPPSYT CFRCGKPGHY IKNCPTNGDK
NFESGPRIKK STGIPRSFMM EVKDPNMKGA MLTNTGKYAI PTIDAEAYAI GKKEKPPFLP
EEPSSSSEED DPIPDELLCL ICKDIMTDAV VIPCCGNSYC DECIRTALLE SDEHTCPTCH
QNDVSPDALI ANKFLRQAVN NFKNETGYTK RLRKQLPPPP PPIPPPRPLI QRNLQPLMRS
PISRQQDPLM IPVTSSSTHP APSISSLTSN QSSLAPPVSG NPSSAPAPVP DITATVSISV
HSEKSDGPFR DSDNKILPAA ALASEHSKGT SSIAITALME EKGYQVPVLG TPSLLGQSLL
HGQLIPTTGP VRINTARPGG GRPGWEHSNK LGYLVSPPQQ IRRGERSCYR SINRGRHHSE
RSQRTQGPSL PATPVFVPVP PPPLYPPPPH TLPLPPGVPP PQFSPQFPPG QPPPAGYSVP
PPGFPPAPAN LSTPWVSSGV QTAHSNTIPT TQAPPLSREE FYREQRRLKE EEKKKSKLDE
FTNDFAKELM EYKKIQKERR RSFSRSKSPY SGSSYSRSSY TYSKSRSGST RSRSYSRSFS
RSHSRSYSRS PPYPRRGRGK SRNYRSRSRS HGYHRSRSRS PPYRRYHSRS RSPQAFRGQS
PNKRNVPQGE TEREYFNRYR EVPPPYDMKA YYGRSVDFRD PFEKERYREW ERKYREWYEK
YYKGYAAGAQ PRPSANRENF SPERFLPLNI RNSPFTRGRR EDYVGGQSHR SRNIGSNYPE
KLSARDGHNQ KDNTKSKEKE SENAPGDGKG NKHKKHRKRR KGEESEGFLN PELLETSRKS
REPTGVEENK TDSLFVLPSR DDATPVRDEP MDAESITFKS VSEKDKRERD KPKAKGDKTK
RKNDGSAVSK KENIVKPAKG PQEKVDGERE RSPRSEPPIK KAKEETPKTD NTKSSSSSQK
DEKITGTPRK AHSKSAKEHQ ETKPVKEEKV KKDYSKDVKS EKLTTKEEKA KKPNEKNKPL
DNKGEKRKRK TEEKGVDKDF ESSSMKISKL EVTEIVKPSP KRKMEPDTEK MDRTPEKDKI
SLSAPAKKIK LNRETGKKIG STENISNTKE PSEKLESTSS KVKQEKVKGK VRRKVTGTEG
SSSTLVDYTS TSSTGGSPVR KSEEKTDTKR TVIKTMEEYN NDNTAPAEDV IIMIQVPQSK
WDKDDFESEE EDVKSTQPIS SVGKPASVIK NVSTKPSNIV KYPEKESEPS EKIQKFTKDV
SHEIIQHEVK SSKNSASSEK GKTKDRDYSV LEKENPEKRK NSTQPEKESN LDRLNEQGNF
KSLSQSSKEA RTSDKHDSTR ASSNKDFTPN RDKKTDYDTR EYSSSKRRDE KNELTRRKDS
PSRNKDSASG QKNKPREERD LPKKGTGDSK KSNSSPSRDR KPHDHKATYD TKRPNEETKS
VDKNPCKDRE KHVLEARNNK ESSGNKLLYI LNPPETQVEK EQITGQIDKS TVKPKPQLSH
SSRLSSDLTR ETDEAAFEPD YNESDSESNV SVKEEESSGN ISKDLKDKIV EKAKESLDTA
AVVQVGISRN QSHSSPSVSP SRSHSPSGSQ TRSHSSSASS AESQDSKKKK KKKEKKKHKK
HKKHKKHKKH AGTEVELEKS QKHKHKKKKS KKNKDKEKEK EKDDQKVKSV TV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	76	Domain	DWNN domain	IPR014891	SM01180
4	76	Domain	DWNN domain	IPR014891	PS51282
4	76	Domain	DWNN domain	IPR014891	PF08783
6	1253	Family	E3 ubiquitin-protein ligase RBBP6 family	IPR033489	PTHR15439
153	179	Homologous_superfamily	Zinc finger, CCHC-type superfamily	IPR036875	SSF57756
156	176	Domain	Zinc knuckle CX2CX3GHX4C	IPR025829	PF13696
160	176	Domain	Zinc finger, CCHC-type	IPR001878	SM00343
161	175	Domain	Zinc finger, CCHC-type	IPR001878	PS50158
245	335	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
253	325	Domain	U-box domain	IPR003613	PF04564
259	299	Domain	Zinc finger, RING-type	IPR001841	SM00184
259	300	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006397	mRNA processing	Biological Process	IEA	GO_REF:0000002
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0006260	DNA replication	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0035264	multicellular organism growth	Biological Process	IEA	GO_REF:0000107
GO:0048568	embryonic organ development	Biological Process	IEA	GO_REF:0000107
GO:0061053	somite development	Biological Process	IEA	GO_REF:0000107
GO:0006275	regulation of DNA replication	Biological Process	IMP	PMID:24726359
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005730	nucleolus	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-983140
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:20873783
GO:0003676	nucleic acid binding	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0003723	RNA binding	Molecular Function	HDA	PMID:22681889
GO:0005515	protein binding	Molecular Function	IPI	PMID:18624398
GO:0019901	protein kinase binding	Molecular Function	IPI	PMID:20873783

Enzyme–Substrate Interactions ▾


Q8NAP3	ZBT38	Yes	Yes	No	No	—	No	E3-specific
P62993	GRB2	Yes	No	No	No	20936779, 21706016	EBI-3440800	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q8NAP3	ZBT38	Yes	Yes	No	No	—	No	E3-specific
P62993	GRB2	Yes	No	No	No	20936779, 21706016	EBI-3440800	E3-specific