BRAP

Details:

UniProt Entry: Q7Z569
Gene: BRAP
Class: RING
Family: RING9
Protein length: 592
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q7Z569
MSVSLVVIRL ELAEHSPVPA GFGFSAAAGE MSDEEIKKTT LASAVACLEG KSPGEKVAII
HQHLGRREMT DVIIETMKSN PDELKTTVEE RKSSEASPTA QRSKDHSKEC INAAPDSPSK
QLPDQISFFS GNPSVEIVHG IMHLYKTNKM TSLKEDVRRS AMLCILTVPA AMTSHDLMKF
VAPFNEVIEQ MKIIRDSTPN QYMVLIKFRA QADADSFYMT CNGRQFNSIE DDVCQLVYVE
RAEVLKSEDG ASLPVMDLTE LPKCTVCLER MDESVNGILT TLCNHSFHSQ CLQRWDDTTC
PVCRYCQTPE PVEENKCFEC GVQENLWICL ICGHIGCGRY VSRHAYKHFE ETQHTYAMQL
TNHRVWDYAG DNYVHRLVAS KTDGKIVQYE CEGDTCQEEK IDALQLEYSY LLTSQLESQR
IYWENKIVRI EKDTAEEINN MKTKFKETIE KCDNLEHKLN DLLKEKQSVE RKCTQLNTKV
AKLTNELKEE QEMNKCLRAN QVLLQNKLKE EERVLKETCD QKDLQITEIQ EQLRDVMFYL
ETQQKINHLP AETRQEIQEG QINIAMASAS SPASSGGSGK LPSRKGRSKR GK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
152	228	Homologous_superfamily	RNA-binding domain superfamily	IPR035979	SSF54928
155	250	Domain	BRCA1-associated 2/ETP1, RRM	IPR011422	PF07576
160	243	Domain	BRAP2, RNA recognition motif	IPR034932	cd12718
260	301	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
263	304	Domain	Zinc finger, RING-type	IPR001841	PF13639
264	304	Domain	Zinc finger, RING-type	IPR001841	PS50089
264	303	Domain	Zinc finger, RING-type	IPR001841	SM00184
301	393	Domain	Zinc finger, UBP-type	IPR001607	PS50271
302	376	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
316	365	Domain	Zinc finger, UBP-type	IPR001607	SM00290
317	376	Domain	Zinc finger, UBP-type	IPR001607	PF02148

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000165	MAPK cascade	Biological Process	IDA	PMID:14724641
GO:0007265	Ras protein signal transduction	Biological Process	IDA	PMID:14724641
GO:0009968	negative regulation of signal transduction	Biological Process	IDA	PMID:14724641
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0031965	nuclear membrane	Cellular Component	IDA	GO_REF:0000052
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:14724641
GO:0003676	nucleic acid binding	Molecular Function	IEA	GO_REF:0000002
GO:0008139	nuclear localization sequence binding	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:14724641
GO:0005515	protein binding	Molecular Function	IPI	PMID:14724641
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:14724641
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9Y4E8	UBP15	Yes	Yes	No	No	—	No	E3-specific
Q9UNH5	CC14A	Yes	Yes	No	No	—	No	E3-specific
Q7Z569	BRAP	Yes	Yes	Yes	No	14724641, 25820252	EBI-350185	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9Y4E8	UBP15	Yes	Yes	No	No	—	No	E3-specific
Q9UNH5	CC14A	Yes	Yes	No	No	—	No	E3-specific
Q7Z569	BRAP	Yes	Yes	Yes	No	14724641, 25820252	EBI-350185	E3-specific