TRI46

Details:

UniProt Entry: Q7Z4K8
Gene: TRIM46
Class: RING
Family: RING8
Protein length: 759
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q7Z4K8
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH NVCQACAREV
LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD RLDRLLKSGF GTYPGRKRGA
LHPQVIMFPC PACQGDVELG ERGLAGLFRN LTLERVVERY RQSVSVGGAI LCQLCKPPPL
EATKGCTECR ATFCNECFKL FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT
CQRLVCQLCR VRRTHSGHKI TPVLSAYQAL KDKLTKSLTY ILGNQDTVQT QICELEEAVR
HTEVSGQQAK EEVSQLVRGL GAVLEEKRAS LLQAIEECQQ ERLARLSAQI QEHRSLLDGS
GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR PAASSSFRHC QLDVGREMKL
LTELNFLRVP EAPVIDTQRT FAYDQIFLCW RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW
QRREEVRGTS ALLENPDTGS VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDSRWG
ASRERLAISK DQRAVRSVPG LPLLLAADRL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP
ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDATVEASPP FAFLTIGMGK
ILLGSGASSN AGLTGRDGPT AGCTVPLPPR LGICLDYERG RVSFLDAVSF RGLLECPLDC
SGPVCPAFCF IGGGAVQLQE PVGTKPERKV TIGGFAKLD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
14	80	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
33	133	Domain	Zinc finger, RING-type	IPR001841	SM00184
48	57	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
222	263	Domain	B-box-type zinc finger	IPR000315	SM00336
222	263	Domain	B-box-type zinc finger	IPR000315	PS50119
225	263	Domain	B-box-type zinc finger	IPR000315	PF00643
370	427	Domain	COS domain	IPR017903	PS51262
373	422	Domain	Midline-1, COS domain	IPR040859	PF18568
425	529	Homologous_superfamily	Fibronectin type III superfamily	IPR036116	SSF49265
427	532	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
429	528	Domain	Fibronectin type III	IPR003961	PS50853
444	525	Domain	Fibronectin type III	IPR003961	cd00063
513	747	Domain	B30.2/SPRY domain	IPR001870	PS50188
532	741	Domain	TRIM46, PRY/SPRY domain	IPR035731	cd12895
539	742	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
545	737	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032880	regulation of protein localization	Biological Process	IEA	GO_REF:0000117
GO:0000226	microtubule cytoskeleton organization	Biological Process	IEA	GO_REF:0000107
GO:0001578	microtubule bundle formation	Biological Process	IEA	GO_REF:0000107
GO:0001764	neuron migration	Biological Process	IEA	GO_REF:0000107
GO:0007409	axonogenesis	Biological Process	IEA	GO_REF:0000107
GO:0048490	anterograde synaptic vesicle transport	Biological Process	IEA	GO_REF:0000107
GO:0099612	protein localization to axon	Biological Process	IEA	GO_REF:0000107
GO:0030517	negative regulation of axon extension	Biological Process	ISS	GO_REF:0000024
GO:1901953	positive regulation of anterograde dense core granule transport	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0044304	main axon	Cellular Component	IEA	GO_REF:0000117
GO:0043194	axon initial segment	Cellular Component	IEA	GO_REF:0000107
GO:1904115	axon cytoplasm	Cellular Component	IEA	GO_REF:0000108
GO:1990769	proximal neuron projection	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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