R144B

Details:

UniProt Entry: Q7Z419
Gene: RNF144B
Class: RBR
Family: RBR
Protein length: 303
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q7Z419
MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY
MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW
CPVADCQTVC PVASSDPGQP VLVECPSCHL KFCSCCKDAW HAEVSCRDSQ PIVLPTEHRA
LFGTDAEAPI KQCPVCRVYI ERNEGCAQMM CKNCKHTFCW YCLQNLDNDI FLRHYDKGPC
RNKLGHSRAS VMWNRTQVVG ILVGLGIIAL VTSPLLLLAS PCIICCVCKS CRGKKKKHDP
STT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
26	233	Family	E3 ubiquitin ligase RBR family	IPR031127	PTHR11685
26	244	Domain	TRIAD supradomain	IPR044066	PS51873
26	115	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
30	78	Domain	Zinc finger, RING-type	IPR001841	SM00184
101	166	Domain	IBR domain	IPR002867	SM00647
102	166	Domain	IBR domain	IPR002867	PF01485
178	240	Domain	IBR domain	IPR002867	SM00647
187	226	Domain	IBR domain	IPR002867	PF01485
193	285	Domain	Zinc finger, RING-type	IPR001841	SM00184
214	223	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA	PMID:20300062
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031966	mitochondrial membrane	Cellular Component	IBA	GO_REF:0000033
GO:0005739	mitochondrion	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-983140
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0031090	organelle membrane	Cellular Component	IEA	GO_REF:0000117
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:12853982
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


O60294	TYW4	Yes	Yes	No	No	—	No	E3-specific
Q07812	BAX	Yes	Yes	Yes	No	20300062	EBI-7860891	Cluster-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O60294	TYW4	Yes	Yes	No	No	—	No	E3-specific
Q07812	BAX	Yes	Yes	Yes	No	20300062	EBI-7860891	Cluster-specific