MAEA

Details:

UniProt Entry: Q7L5Y9
Gene: MAEA
Class: RING
Family: RING1
Protein length: 396
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q7L5Y9
MAVQESAAQL SMTLKVQEYP TLKVPYETLN KRFRAAQKNI DRETSHVTMV VAELEKTLSG
CPAVDSVVSL LDGVVEKLSV LKRKAVESIQ AEDESAKLCK RRIEHLKEHS SDQPAAASVW
KRKRMDRMMV EHLLRCGYYN TAVKLARQSG IEDLVNIEMF LTAKEVEESL ERRETATCLA
WCHDNKSRLR KMKSCLEFSL RIQEFIELIR QNKRLDAVRH ARKHFSQAEG SQLDEVRQAM
GMLAFPPDTH ISPYKDLLDP ARWRMLIQQF RYDNYRLHQL GNNSVFTLTL QAGLSAIKTP
QCYKEDGSSK SPDCPVCSRS LNKLAQPLPM AHCANSRLVC KISGDVMNEN NPPMMLPNGY
VYGYNSLLSI RQDDKVVCPR TKEVFHFSQA EKVYIM

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
13	394	Family	Fyv10 family	IPR045098	PTHR12170
121	153	Domain	LIS1 homology motif	IPR006594	SM00667
121	153	Domain	LIS1 homology motif	IPR006594	PS50896
159	216	Domain	CTLH, C-terminal LisH motif	IPR006595	PS50897
159	216	Domain	CTLH, C-terminal LisH motif	IPR006595	SM00668
161	300	Domain	CTLH/CRA C-terminal to LisH motif domain	IPR024964	PF10607
212	306	Domain	CRA domain	IPR013144	SM00757
314	381	Domain	Gid-type RING finger domain	IPR044063	PS51867

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0043249	erythrocyte maturation	Biological Process	IEA	GO_REF:0000043
GO:0007010	cytoskeleton organization	Biological Process	IEA	GO_REF:0000107
GO:0048821	erythrocyte development	Biological Process	IEA	GO_REF:0000107
GO:0048822	enucleate erythrocyte development	Biological Process	IEA	GO_REF:0000107
GO:0007155	cell adhesion	Biological Process	IDA	PMID:9763581
GO:0007346	regulation of mitotic cell cycle	Biological Process	NAS	PMID:16510120
GO:0033033	negative regulation of myeloid cell apoptotic process	Biological Process	IDA	PMID:9763581
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016363	nuclear matrix	Cellular Component	IEA	GO_REF:0000044
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005819	spindle	Cellular Component	IDA	PMID:16510120
GO:0005826	actomyosin contractile ring	Cellular Component	IDA	PMID:16510120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-9861563
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0015629	actin cytoskeleton	Cellular Component	IEA	GO_REF:0000107
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:29911972
GO:0034657	GID complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.