HECW1

Details:

UniProt Entry: Q76N89
Gene: HECW1
Class: HECT
Family: HECT1
Protein length: 1606
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3l4h

Protein Sequence ▾

>Q76N89
MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV
LSENFLDYKN RGVNGSHRGQ IIWKIDASSY FVEPETKICF KYYHGVSGAL RATTPSVTVK
NSAAPIFKSI GADETVQGQG SRRLISFSLS DFQAMGLKKG MFFNPDPYLK ISIQPGKHSI
FPALPHHGQE RRSKIIGNTV NPIWQAEQFS FVSLPTDVLE IEVKDKFAKS RPIIKRFLGK
LSMPVQRLLE RHAIGDRVVS YTLGRRLPTD HVSGQLQFRF EITSSIHPDD EEISLSTEPE
SAQIQDSPMN NLMESGSGEP RSEAPESSES WKPEQLGEGS VPDGPGNQSI ELSRPAEEAA
VITEAGDQGM VSVGPEGAGE LLAQVQKDIQ PAPSAEELAE QLDLGEEASA LLLEDGEAPA
STKEEPLEEE ATTQSRAGRE EEEKEQEEEG DVSTLEQGEG RLQLRASVKR KSRPCSLPVS
ELETVIASAC GDPETPRTHY IRIHTLLHSM PSAQGGSAAE EEDGAEEEST LKDSSEKDGL
SEVDTVAADP SALEEDREEP EGATPGTAHP GHSGGHFPSL ANGAAQDGDT HPSTGSESDS
SPRQGGDHSC EGCDASCCSP SCYSSSCYST SCYSSSCYSA SCYSPSCYNG NRFASHTRFS
SVDSAKISES TVFSSQDDEE EENSAFESVP DSMQSPELDP ESTNGAGPWQ DELAAPSGHV
ERSPEGLESP VAGPSNRREG ECPILHNSQP VSQLPSLRPE HHHYPTIDEP LPPNWEARID
SHGRVFYVDH VNRTTTWQRP TAAATPDGMR RSGSIQQMEQ LNRRYQNIQR TIATERSEED
SGSQSCEQAP AGGGGGGGSD SEAESSQSSL DLRREGSLSP VNSQKITLLL QSPAVKFITN
PEFFTVLHAN YSAYRVFTSS TCLKHMILKV RRDARNFERY QHNRDLVNFI NMFADTRLEL
PRGWEIKTDQ QGKSFFVDHN SRATTFIDPR IPLQNGRLPN HLTHRQHLQR LRSYSAGEAS
EVSRNRGASL LARPGHSLVA AIRSQHQHES LPLAYNDKIV AFLRQPNIFE MLQERQPSLA
RNHTLREKIH YIRTEGNHGL EKLSCDADLV ILLSLFEEEI MSYVPLQAAF HPGYSFSPRC
SPCSSPQNSP GLQRASARAP SPYRRDFEAK LRNFYRKLEA KGFGQGPGKI KLIIRRDHLL
EGTFNQVMAY SRKELQRNKL YVTFVGEEGL DYSGPSREFF FLLSQELFNP YYGLFEYSAN
DTYTVQISPM SAFVENHLEW FRFSGRILGL ALIHQYLLDA FFTRPFYKAL LRLPCDLSDL
EYLDEEFHQS LQWMKDNNIT DILDLTFTVN EEVFGQVTER ELKSGGANTQ VTEKNKKEYI
ERMVKWRVER GVVQQTEALV RGFYEVVDSR LVSVFDAREL ELVIAGTAEI DLNDWRNNTE
YRGGYHDGHL VIRWFWAAVE RFNNEQRLRL LQFVTGTSSV PYEGFAALRG SNGLRRFCIE
KWGKITSLPR AHTCFNRLDL PPYPSYSMLY EKLLTAVEET STFGLE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
65	183	Domain	E3 ubiquitin-protein ligase HECW1/2, N-terminal	IPR032348	PF16562
182	318	Domain	C2 domain	IPR000008	PS50004
205	341	Domain	E3 ubiquitin-protein ligase HECW, C2 domain	IPR037795	cd08691
206	317	Domain	C2 domain	IPR000008	SM00239
210	314	Domain	C2 domain	IPR000008	PF00168
210	371	Homologous_superfamily	C2 domain superfamily	IPR035892	G3DSA:2.60.40.150
213	311	Homologous_superfamily	C2 domain superfamily	IPR035892	SSF49562
826	862	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
829	862	Domain	WW domain	IPR001202	PS50020
830	862	Domain	WW domain	IPR001202	SM00456
831	860	Domain	WW domain	IPR001202	PF00397
832	861	Domain	WW domain	IPR001202	cd00201
835	860	Domain	WW domain	IPR001202	PS01159
949	1014	Domain	E3 ubiquitin-protein ligase HECW1, helical box domain	IPR040524	PF18436
1010	1052	Homologous_superfamily	WW domain superfamily	IPR036020	SSF51045
1018	1051	Domain	WW domain	IPR001202	PS50020
1019	1051	Domain	WW domain	IPR001202	SM00456
1021	1051	Domain	WW domain	IPR001202	cd00201
1024	1049	Domain	WW domain	IPR001202	PS01159
1240	1600	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
1250	1604	Domain	HECT domain	IPR000569	cd00078
1269	1606	Domain	HECT domain	IPR000569	SM00119
1271	1606	Domain	HECT domain	IPR000569	PS50237
1302	1605	Domain	HECT domain	IPR000569	PF00632

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0048814	regulation of dendrite morphogenesis	Biological Process	IBA	GO_REF:0000033
GO:0090090	negative regulation of canonical Wnt signaling pathway	Biological Process	TAS	Reactome:R-HSA-4641258
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-4641155
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


O14640	DVL1	Yes	Yes	No	No	—	No	E3-specific

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