HAKAI

>Q75N03
MDHTDNELQG TNSSGSLGGL DVRRRIPIKL ISKQANKAKP APRTQRTINR MPAKAPPGDE
EGFDYNEEER YDCKGGELFA NQRRFPGHLF WDFQINILGE KDDTPVHFCD KCGLPIKIYG
RMIPCKHVFC YDCAILHEKK GDKMCPGCSD PVQRIEQCTR GSLFMCSIVQ GCKRTYLSQR
DLQAHINHRH MRAGKPVTRA SLENVHPPIA PPPTEIPERF IMPPDKHHMS HIPPKQHIMM
PPPPLQHVPH EHYNQPHEDI RAPPAELSMA PPPPRSVSQE TFRISTRKHS NLITVPIQDD
SNSGAREPPP PAPAPAHHHP EYQGQPVVSH PHHIMPPQQH YAPPPPPPPP ISHPMPHPPQ
AAGTPHLVYS QAPPPPMTSA PPPITPPPGH IIAQMPPYMN HPPPGPPPPQ HGGPPVTAPP
PHHYNPNSLP QFTEDQGTLS PPFTQPGGMS PGIWPAPRGP PPPPRLQGPP SQTPLPGPHH
PDQTRYRPYY Q

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
5	491	Family	E3 ubiquitin-protein ligase HAKAI/CBLL2	IPR040383	PTHR13480
106	164	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
107	148	Domain	HAKAI-like, RING finger, HC subclass	IPR040380	cd16508
109	149	Domain	Zinc finger, RING-type	IPR001841	PS50089
125	134	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
161	192	Domain	Hakai, C2H2 zinc finger domain	IPR041042	PF18408

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0007162	negative regulation of cell adhesion	Biological Process	IEA	GO_REF:0000107
GO:0030335	positive regulation of cell migration	Biological Process	IEA	GO_REF:0000107
GO:0045807	positive regulation of endocytosis	Biological Process	IEA	GO_REF:0000107
GO:0006397	mRNA processing	Biological Process	IMP	PMID:29507755
GO:0030155	regulation of cell adhesion	Biological Process	IBA	GO_REF:0000033
GO:0098609	cell-cell adhesion	Biological Process	IDA	PMID:11836526
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0016607	nuclear speck	Cellular Component	IEA	GO_REF:0000044
GO:0036396	RNA N6-methyladenosine methyltransferase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8876993
GO:0000151	ubiquitin ligase complex	Cellular Component	IC	PMID:14996930
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000002
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:11836526
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000107

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q93070	NAR4	Yes	Yes	No	No	—	No	E3-specific