FBX50

Details:

UniProt Entry: Q6ZVX7
Gene: NCCRP1
Class: Other E3 Components
Family: Receptor
Protein length: 275
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6ZVX7
MEEVREGHAL GGGMEADGPA SLQELPPSPR SPSPPPSPPP LPSPPSLPSP AAPEAPELPE
PAQPSEAHAR QLLLEEWGPL SGGLELPQRL TWKLLLLRRP LYRNLLRSPN PEGINIYEPA
PPTGPTQRPL ETLGNFRGWY IRTEKLQQNQ SWTVKQQCVD LLAEGLWEEL LDDEQPAITV
MDWFEDSRLD ACVYELHVWL LAADRRTVIA QHHVAPRTSG RGPPGRWVQV SHVFRHYGPG
VRFIHFLHKA KNRMEPGGLR RTRVTDSSVS VQLRE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
55	275	Family	F-box only protein	IPR039752	PTHR12125
92	272	Homologous_superfamily	Galactose-binding-like domain superfamily	IPR008979	SSF49785
92	273	Domain	F-box associated (FBA) domain	IPR007397	SM01198
95	273	Domain	F-box associated (FBA) domain	IPR007397	PS51114
98	271	Domain	F-box associated (FBA) domain	IPR007397	PF04300

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006516	glycoprotein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0008284	positive regulation of cell population proliferation	Biological Process	IDA	PMID:22087255
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0036503	ERAD pathway	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183

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